Vera Therapeutics Unveils Groundbreaking Atacicept Findings
Vera Therapeutics Unveils Groundbreaking Atacicept Findings
Vera Therapeutics, Inc. (Nasdaq: VERA) is a clinical-stage biotechnology company dedicated to developing transformative treatments for patients with serious immunological conditions. At the upcoming American Society of Nephrology (ASN) Kidney Week, Vera is set to present significant findings from its ORIGIN Phase 2b clinical trial of atacicept, specifically focusing on its long-term effects on immunoglobulin A nephropathy (IgAN).
Presentation Highlights at ASN Kidney Week 2024
This year, ASN Kidney Week will take place in San Diego, California, from October 23 to 27. Vera Therapeutics has secured a late-breaking oral presentation to share the long-term outcomes of the ORIGIN Phase 2b study. Additionally, two informational posters will highlight related studies: ORIGIN Phase 3 and ORIGIN Extend trials of atacicept.
Details of the Oral Presentation
The presentation titled “Long-term Results from the ORIGIN Phase 2b Study of Atacicept for the Treatment of IgAN” will be delivered by Dr. Jonathan Barratt from the University of Leicester. Attendees can expect detailed insights into the therapy's efficacy and safety profile in managing IgAN.
Poster Presentations at ASN Kidney Week
Vera has also organized two poster sessions on October 25, featuring:
- ORIGIN 3 Study: A randomized, controlled Phase 3 trial led by Dr. Richard Lafayette.
- ORIGIN Extend Study: Focusing on the long-term implications of atacicept, also presented by Dr. Lafayette.
Both posters aim to further elucidate the impact of atacicept in chronic kidney disease stemming from autoimmune disorders.
Upcoming R&D Day in New York
Vera is excited to announce an R&D Day event scheduled for October 2, featuring in-person and virtual participation options. This event promises to be informative, with presentations by key researchers, including Dr. Jonathan Barratt and Dr. Richard Lafayette. They will discuss Vera's strategic direction in expanding atacicept research and development efforts.
Engagement Opportunities During R&D Day
Following their presentations, attendees will have the chance to engage in a live Q&A session, fostering an interactive environment for inquiries regarding the latest clinical research findings and Vera's innovative approach in treating serious immunological diseases.
About Vera Therapeutics
Vera Therapeutics remains committed to revolutionizing treatments for serious immunological diseases through innovative solutions. The company's lead product, atacicept, is self-administered weekly and aims to mitigate the effects of autoimmune disorders by targeting specific pathways that enable B cells and plasma cells to generate harmful autoantibodies. This compound shows significant promise in the management of IgAN, also recognized as Berger’s disease.
Atacicept's Clinical Achievements
The Phase 2b ORIGIN trial demonstrated promising results, achieving both primary and secondary endpoints with notable reductions in proteinuria and stabilization of kidney function. The data collected over 36 weeks highlights the potential for atacicept to offer significant improvements compared to existing therapies.
Regulatory Recognition
Atacicept has garnered FDA Breakthrough Therapy Designation, indicative of its potential to address unmet medical needs for patients suffering from IgAN. Such recognition underscores the favorable results observed during clinical evaluations, emphasizing the treatment's success in subduing autoimmune responses through established mechanisms.
Frequently Asked Questions
What are the key results from the ORIGIN Phase 2b trial?
The Phase 2b trial showed significant reductions in proteinuria and stabilization of kidney function in patients treated with atacicept.
When and where will the ASN Kidney Week take place?
ASN Kidney Week is scheduled for October 23-27 in San Diego, California.
Who will present the findings at ASN Kidney Week?
Dr. Jonathan Barratt will present the findings from the ORIGIN Phase 2b study during the oral presentation.
What is the purpose of the R&D Day hosted by Vera?
The R&D Day aims to discuss upcoming research activities and engage with researchers and stakeholders about atacicept's development.
What is atacicept's mechanism of action?
Atacicept is designed to target and inhibit the action of harmful cytokines that promote the survival of B cells, reducing autoantibody production related to autoimmune diseases.
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