TG Therapeutics Highlights New Insights on BRIUMVI in MS

Two New Publications Showcase BRIUMVI's Impact

TG Therapeutics, Inc. (NASDAQ: TGTX) recently announced the release of two significant journal articles focusing on BRIUMVI (ublituximab-xiiy), a novel treatment for multiple sclerosis (MS). One article reviews the progression of CD20 therapies, while the other provides insights from several patients who switched to BRIUMVI due to issues with their previous treatments. These publications offer valuable information about the real-world application and effectiveness of BRIUMVI.

Case Studies Highlighting Patient Experiences

Understanding the Switch to Ublituximab

One of the key publications, titled "Switching to Ublituximab from Prior Anti-CD20 Monoclonal Antibody Therapy: A Case Report Series," details a retrospective series involving seven individuals with MS. These patients transitioned from other anti-CD20 therapies to BRIUMVI due to concerns about efficacy or tolerability. The report outlines their clinical outcomes after switching, offering compelling anecdotal evidence about the therapy's effectiveness.

The Evolution of Anti-CD20 Therapies

Insights from the Progression of Treatment

Another article, titled "The Evolution of Anti-CD20 Treatment for Multiple Sclerosis," dives into the unique attributes of anti-CD20 monoclonal antibodies and their relevance in treating MS. It discusses how variations in therapeutic efficacy, tolerability, and patient experiences can be linked to differences in the structures and functions of these antibodies. Such insights are crucial for understanding the rationale behind switching treatments within the CD20 class.

Ongoing Commitment to Multiple Sclerosis Research

Michael S. Weiss, the Executive Chairman and CEO of TG Therapeutics, expressed optimism regarding these publications. He noted, "We believe they provide a rationale for encouraging patients to switch between therapies within the CD20 class before leaving it altogether... Our commitment to the MS community is reinforced by these findings, and we will continue to investigate BRIUMVI's impacts through our ongoing studies, including ENHANCE and ENABLE."

BRIUMVI: A New Approach to MS Treatment

BRIUMVI is a groundbreaking monoclonal antibody specifically designed to interact with a distinct epitope on CD20-expressing B-cells. This innovative treatment approach has shown promise in effectively managing MS, including relapsing forms of the disease. The glycoengineering used in developing BRIUMVI allows for efficient depletion of B-cells at lower dosages, aiming to improve patient outcomes.

Important Information About BRIUMVI

BRIUMVI is primarily indicated for adults diagnosed with relapsing forms of multiple sclerosis, such as clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. As a rapidly evolving area of research, the experience gathered from clinical applications like BRIUMVI can significantly enhance treatment strategies for MS patients globally.

Fostering Patient Support

TG Therapeutics has established the BRIUMVI Patient Support program, tailored to assist patients throughout their treatment journey. This flexible program aims to adapt to the needs of each patient, ensuring they receive comprehensive support as they navigate living with MS.

Frequently Asked Questions

What is BRIUMVI and how does it work?

BRIUMVI (ublituximab-xiiy) is a monoclonal antibody that targets CD20-expressing B-cells, designed to treat relapsing forms of multiple sclerosis.

What evidence do the new publications provide?

The publications highlight patient experiences with BRIUMVI after switching from other therapies and discuss the evolution of anti-CD20 treatments.

What are the benefits of switching to BRIUMVI?

Patients may experience improved efficacy and tolerability, which are crucial for managing their symptoms and overall health.

Are there any safety concerns with BRIUMVI?

BRIUMVI may cause infusion reactions and increase the risk of infections; it is important to monitor patients closely during treatment.

How can patients access BRIUMVI?

Patients can receive BRIUMVI through authorized specialty distributors and should consult with their healthcare providers for more information.

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