Sysmex Inostics Launches RAS-RAF-SEQ Liquid Biopsy Assay
Sysmex Inostics Introduces Approved RAS-RAF-SEQ Assay
Sysmex Inostics Inc., a research-driven biotechnology firm and subsidiary of Japan's Sysmex Corporation, is thrilled to announce its revolutionary RAS-RAF-SEQ Laboratory Developed Test has successfully obtained approval from the New York State Department of Health Clinical Laboratory Evaluation Program for use in clinical trials. This endorsement marks a significant milestone, enhancing the way cancer is diagnosed and treated.
Overview of the RAS-RAF-SEQ Assay
The RAS-RAF-SEQ assay represents a forefront advancement in liquid biopsy technology. It is a clinically validated tool that identifies five crucial genetic targets relevant to various cancers influenced by the RAS-RAF and PI3K pathways, including colorectal, pancreatic, gallbladder, ovarian, and lung cancers. The utilization of this diagnostic test holds promise for providing deeper insights into patient-specific therapies.
Significance of NY State CLEP Approval
Shinichi Sato, the President and CEO of Sysmex Inostics, emphasized the importance of the NY State CLEP approval, stating, "This will afford pharmaceutical and clinical trial researchers in New York a non-invasive method to gain greater insight into innovative treatment strategies for a range of RAS-RAF and PI3K-related cancers." This non-invasive approach presents a new horizon in patient care, reflecting the commitment of Sysmex Inostics to deliver advanced diagnostic solutions.
Understanding the RAS-RAF Pathway
Genetic alterations within the RAS-RAF signaling pathway, specifically involving mutations such as KRAS, NRAS, and BRAF, are frequently observed across diverse cancer types. These mutations play a critical role in the mechanisms driving cancer progression and can greatly influence the response to therapies. Identifying these alterations through the RAS-RAF-SEQ assay permits healthcare providers to select the most effective treatment options, thereby enhancing patient management.
Ultra-sensitive Detection with Plasma-Safe-SeqS
One of the standout features of the RAS-RAF-SEQ assay is its Plasma-Safe-SeqS technology, which is adept at conserving all input molecules during analysis. This innovative technology enables the detection of low-frequency genomic mutations at remarkable sensitivity. Jonathan Craft, Associate Director of Translational Research at Sysmex Inostics, underscored this innovation, stating, "The RAS-RAF-SEQ assay delivers ultra-sensitivity with robust specificity for the targeted mutations within RAS-RAF and PI3K pathways, thus ensuring enhanced diagnostic accuracy."
Improving Cancer Treatment Outcomes
The RAS-RAF-SEQ assay not only identifies existing mutations but also tracks emerging resistance mutations that may develop over the course of treatment. By providing a comprehensive view of a patient’s genetic landscape, the test facilitates informed therapeutical decision-making, ensuring optimal care and minimizing undesirable treatment effects.
About Sysmex Inostics
Sysmex Inostics, renowned for its innovative contributions to personalized medicine, operates as a leading biotechnology firm and CLIA-certified laboratory. By harnessing advanced liquid biopsy technology since its inception of the OncoBEAM™ platform in 2008, Sysmex Inostics has continually aimed to enhance the detection of low-frequency biomarkers through its next-generation sequencing panels, achieving ultra-sensitive allele frequencies from blood samples. Their services expand into the domains of HPV quantification and various cancers affected by the RAS-RAF and PI3K pathways.
Frequently Asked Questions
What is the RAS-RAF-SEQ assay?
The RAS-RAF-SEQ assay is a CLIA-validated liquid biopsy tool designed to identify critical genomic mutations related to cancer.
What types of cancer does the RAS-RAF-SEQ target?
The assay targets mutations relevant to colorectal, pancreatic, gallbladder, ovarian, and lung cancers.
How does the Plasma-Safe-SeqS technology work?
The Plasma-Safe-SeqS technology preserves all molecules during analysis, enhancing the detection of low-level genomic mutations with high sensitivity.
Who can benefit from the RAS-RAF-SEQ assay?
Pharmaceutical developers and clinical trial investigators can leverage the assay for improved insights in cancer treatment strategies.
Is Sysmex Inostics associated with any larger corporations?
Yes, Sysmex Inostics is a subsidiary of Sysmex Corporation, based in Japan, specializing in innovative medical diagnostics.
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