Revolutionizing Prostate Cancer Treatment with ATNM-400

Actinium Pharmaceuticals Unveils ATNM-400, a Game Changer in Prostate Cancer Therapy

Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM), renowned for pioneering targeted radiotherapies, has announced a breakthrough product, ATNM-400. This innovative radiotherapy aims to treat prostate cancer without relying on the Prostate-Specific Membrane Antigen (PSMA) targeting mechanisms that many current treatments depend on. Utilizing the powerful Actinium-225 (Ac-225) isotope, ATNM-400 showcases a unique approach to combatting prostate cancer.

Impressive Preclinical Results of ATNM-400

Recent preclinical studies have demonstrated remarkable findings for ATNM-400. Notably, a single dose administered in prostate cancer models achieved a staggering 99.8% tumor growth inhibition. This level of efficacy positions ATNM-400 as a promising alternative, especially for patients not responding to existing therapies, like Pluvicto, which targets PSMA directly.

In these studies, ATNM-400 displayed an ability to stay present in tumor tissues for up to 144 hours while showcasing minimal absorption in surrounding healthy tissues. This characteristic is crucial for reducing potential side effects typically associated with cancer treatments.

Insights from Upcoming AACR Presentation

The American Association for Cancer Research (AACR) Annual Meeting will highlight the latest findings related to ATNM-400, including essential biodistribution imaging and various efficacy analyses. Among the exciting aspects to be unveiled is the performance of ATNM-400 in cell lines resistant to Pluvicto, which could provide insights into the next steps for external application in real-world scenarios.

Addressing Unmet Medical Needs

Sandesh Seth, the Chairman and CEO of Actinium, expressed confidence in the potential of ATNM-400, particularly noting its capacity to handle patients who may not respond to PSMA-targeting therapies. The precision of the Ac-225 isotope may lead to better patient tolerability and less toxicity while maintaining efficacy. Seth emphasized, "We are eager to present our ATNM-400 data at AACR and to continue to advance this highly novel prostate cancer candidate." This optimistic view underlines the ongoing commitment to improving outcomes for cancer patients.

Key Highlights from Preclinical Data

• ATNM-400 has demonstrated selective binding to prostate cancer cells, allowing for efficient internalization and dose-dependent cytotoxic effects.
• In animal models, this radiotherapy option exhibited the ability to concentrate in tumors while avoiding healthy tissue damage.
• Imaging studies using Indium-111-labeled antibodies confirmed the selective tumor accumulation of ATNM-400 and its rapid clearance from healthy tissues.
• A single dose of ATNM-400 resulted in significant tumor growth inhibition—68.5% at 20 µCi/kg and an impressive 99.8% at 40 µCi/kg—while also being well tolerated by subjects.

About Actinium Pharmaceuticals

Actinium Pharmaceuticals continues to lead innovative advancements in radiotherapy designed to enhance patient outcomes. The company is also actively developing its lead product, Actimab-A, aimed at treating acute myeloid leukemia (AML) and other myeloid malignancies. Leveraging Actinium-225 as the payload, Actimab-A has shown promise in treating relapsed AML patients.

Beyond its proprietary treatments, Actinium collaborates with the National Cancer Institute (NCI) to further develop potential therapies for AML. This collaborative spirit indicates the company’s resolve to impact patient care positively, leading to the advancement of treatments that could address significant gaps in current therapies.

Investing in the Future of Cancer Therapies

As Actinium Pharmaceuticals strides forward, it remains dedicated to advancing its research and development initiatives. The pipeline of innovative programs aimed at solid tumors signifies the broad spectrum of potential applications for Actinium's technologies. With its commitment to patient welfare, Actinium expects to achieve great strides in cancer treatment in the years to come.

Frequently Asked Questions

What is ATNM-400?

ATNM-400 is a novel radiotherapy developed by Actinium Pharmaceuticals for the treatment of prostate cancer, utilizing the Actinium-225 isotope.

How effective is ATNM-400 based on early studies?

Early studies indicate that ATNM-400 can inhibit tumor growth by 99.8% at certain doses, marking a significant achievement in preclinical models.

Where will the latest ATNM-400 findings be presented?

Findings on ATNM-400 will be presented at the upcoming AACR Annual Meeting, including detailed results from preclinical studies.

What differentiates ATNM-400 from other therapies?

Unlike other therapies that target PSMA, ATNM-400 targets a different tumor marker, which is overexpressed in prostate cancer, potentially reducing toxicity seen with PSMA therapies.

What is Actinium Pharmaceuticals focusing on currently?

Actinium Pharmaceuticals is focused on advancing diverse therapies targeted at various cancers while continuing to improve patient outcomes through innovative radiotherapy approaches.

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