Provectus Biopharmaceuticals Showcases Innovative Vaccine Adjuvant

Provectus Biopharmaceuticals Innovates with PV-10

KNOXVILLE, Tenn. — Provectus Biopharmaceuticals, Inc. (“Provectus” or the “Company”) (OTCQB: PVCT) has recently made significant waves in the field of immunotherapy with the announcement of groundbreaking independent research conducted by Dr. Aru Narendran and his team at the University of Calgary. This research, published in Human Vaccines & Immunotherapeutics, underscores the transformational potential of PV-10, a proprietary active pharmaceutical ingredient derived from rose bengal sodium, which triggers the body’s STING (stimulator of interferon genes) immune pathway, thereby enhancing antigen presentation and T-cell responses.

The New Potential of PV-10

The research article, titled “PV-10 as New Adjuvant Enhances Immune Responses in Hepatitis B Vaccination Through STING Pathway,” details PV-10's unique mechanism that could position it as a safer and more effective alternative to traditional vaccine adjuvants often critiqued for their safety concerns. With the capability to stimulate the immune response more effectively than common adjuvants like aluminum salts and emulsions, PV-10 emerges as a game-changer in vaccine development.

Research Highlights and Findings

Initial findings from the research highlight the remarkable benefits of PV-10 in immunological responses:

• PV-10 stabilizes STING dimerization, crucial for activating innate immune mechanisms.
• It upregulates key pro-inflammatory cytokines and chemokines essential for adaptive immune responses.
• Significantly enhances IFN-gamma secretion by T cells that have been primed by antigens.

Such profound findings showcase PV-10's potential not just to assist immune non-responders—those who do not gain immunity from existing vaccines—but to serve as a cleaner activator of the immune system across various fields of infectious diseases, oncology, and public health preparedness.

Expert Insights and Market Potential

Dominic Rodrigues, President and Vice Chair of Provectus, expressed optimism over the research outcomes stating, “PV-10 represents more than a treatment for cancer; it is positioned to become a platform for immune enhancement. By leveraging the natural STING pathway, we aim to provide a safer and more effective means of bolstering immunity.” He further emphasized that PV-10 could enable Provectus to tap into substantial multi-billion dollar markets while potentially providing safer options for patients.

Exploring Market Opportunities

The vaccines and adjuvants market is poised for significant growth, expected to exceed $2 billion annually by 2030. PV-10 stands out with its differentiated safety profile and unique mechanism. This opens doors for Provectus across several lucrative sectors:

• Infectious Disease Vaccines: With global vaccine sales projected to surpass $70 billion, PV-10 can address the adverse reactions seen in approximately 10% of healthy individuals who do not respond to existing vaccines like hepatitis B.
• Oncology Vaccines: The oncology vaccine market is set to surpass $10 billion by 2032, necessitating effective immune activation. PV-10's activity could enhance the efficacy of existing checkpoint inhibitors, which currently dominate the market with annual revenues exceeding $40 billion.
• Preparedness Programs: In light of increased epidemic and pandemic threats, safer, more effective adjuvants are a critical need in governmental and non-governmental strategies worldwide.

As emerging research continues to unveil the capabilities of PV-10, the potential benefits could markedly improve protection for underprivileged populations often overlooked by standard vaccination strategies.

About Provectus

Provectus Biopharmaceuticals, Inc. operates within the clinical-stage biotechnology sector, focusing on developing innovative immunotherapy medicines derived from rose bengal sodium. The company’s diverse clinical pipeline encompasses oncology, dermatology, ophthalmology, and additional programs aimed at hematology, wound healing, and infectious diseases.

Frequently Asked Questions

What is PV-10?

PV-10 is a proprietary formulation of the active pharmaceutical ingredient rose bengal sodium, used to enhance immune responses in vaccine development.

How does PV-10 work?

PV-10 activates the STING immune pathway, leading to improved antigen presentation and T-cell activation, enhancing the body’s immune response.

What are the potential markets for PV-10?

PV-10 has potential applications in infectious disease vaccines, oncology, and public health preparedness programs, tapping into burgeoning multi-billion dollar markets.

What were the main findings of the University of Calgary research?

The research highlighted PV-10's ability to stabilize STING dimerization, increase critical immune signaling molecules, and boost production of T-cell responses.

How can PV-10 improve vaccine responses?

By providing a safer alternative to traditional adjuvants, PV-10 could enhance immune responses, particularly for individuals who do not respond to current vaccines.

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