3x more New MANF Research Article - what a pace in
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Posted On: 08/25/2023 11:34:01 PM
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3x more New MANF Research Article - what a pace in 2023
1. Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) expression offers protection against alcohol neurotoxicity
Journal of Neurochemistry . 2023 Jul 28. doi: 10.1111/jnc.15921.
From Iowa/Vanderbilt
"MANF upregulation by the addition of recombinant MANF protein or adenovirus gene transduction protected neuronal cells against alcohol-induced cell death...Exogenous MANF was able to protect against alcohol-induced neurodegeneration."
2.MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis
https://doi.org/10.1016/j.apsb.2023.07.027
From Anhui Medical University in Journal of Acta Pharmaceutica Sinica B
"Pharmacologically, systemic administration of recombinant human MANF significantly alleviated CCl4-induced hepatic fibrosis in both WT and hepatocytes-specific MANF knockout (HKO) mice. This study reveals a mechanism by which MANF targets S100A8/A9-TLR4 as a “brake” on the upstream of NF-κB pathway, which exerts an impact on macrophage differentiation and shed light on hepatic fibrosis treatment."
3. The neurotrophic factor MANF regulates autophagic flux and lysosome function to promote proteostasis in C. elegans
https://doi.org/10.1101/2023.07.31.551399
From Mcmaster University
"MANF-1 regulates protein homeostasis through increased lysosome activity and autophagic flux. Collectively, our work provides a novel understanding of MANF-1 function in promoting neuronal health, stress response, proteostasis, and lifespan of animals."
1. Upregulation of mesencephalic astrocyte-derived neurotrophic factor (MANF) expression offers protection against alcohol neurotoxicity
Journal of Neurochemistry . 2023 Jul 28. doi: 10.1111/jnc.15921.
From Iowa/Vanderbilt
"MANF upregulation by the addition of recombinant MANF protein or adenovirus gene transduction protected neuronal cells against alcohol-induced cell death...Exogenous MANF was able to protect against alcohol-induced neurodegeneration."
2.MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis
https://doi.org/10.1016/j.apsb.2023.07.027
From Anhui Medical University in Journal of Acta Pharmaceutica Sinica B
"Pharmacologically, systemic administration of recombinant human MANF significantly alleviated CCl4-induced hepatic fibrosis in both WT and hepatocytes-specific MANF knockout (HKO) mice. This study reveals a mechanism by which MANF targets S100A8/A9-TLR4 as a “brake” on the upstream of NF-κB pathway, which exerts an impact on macrophage differentiation and shed light on hepatic fibrosis treatment."
3. The neurotrophic factor MANF regulates autophagic flux and lysosome function to promote proteostasis in C. elegans
https://doi.org/10.1101/2023.07.31.551399
From Mcmaster University
"MANF-1 regulates protein homeostasis through increased lysosome activity and autophagic flux. Collectively, our work provides a novel understanding of MANF-1 function in promoting neuronal health, stress response, proteostasis, and lifespan of animals."
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