Quote:IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway.
Discovered in 1991,[19] IL-10 was initially reported to suppress cytokine secretion, antigen presentation and CD4+ T cell activation.[20][21][22][23] Further investigation has shown that IL-10 predominantly inhibits lipopolysaccharide (LPS) and bacterial product mediated induction of the pro-inflammatory cytokines TNFα,[24] IL-1β,[24] IL-12,[25] and IFNγ[26] secretion from Toll-Like Receptor (TLR) triggered myeloid lineage cells.
Effect on tumors
Over time a more nuanced picture of IL-10's function has emerged as treatment of tumor bearing mice has been shown to inhibit tumor metastasis.[27] Additional investigation by multiple laboratories has generated data that further supports IL-10's immunostimulatory capacity in an immunoncology context. Expression of IL-10 from transfected tumor cell lines[28][29] in IL-10 transgenic mice[30] or dosing with IL-10 leads to control of primary tumor growth and decreased metastatic burden.[31][32] More recently, PEGylated recombinant murine IL-10 (PEG-rMuIL-10) has been shown to induce IFNγ and CD8+ T cell dependent anti-tumor immunity.[33][34] More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion.[35]
from here: https://en.wikipedia.org/wiki/Interleukin_10
If all Leronlimab did was reduce inflammation why would it REDUCE IL-10 when IL-10 was anti-inflammatory? IL-10 is a great anti-inflammatory and that is what you think LRM does.
No, LRM, stimulates the immune system to get the job done. We have had this conversation before. LRM allows the appropriate communication between the immune cells so that it can do the job it was meant to do, which is to restore health. When health is restored, there, you have your anti-inflammatory effect. When it is in the process of restoring health, you will see a properly executing immune system with elevations in inflammatory markers or cytokines, but that will soon result in an improved picture of health which will be reflected in a reduction in inflammation and associated markers.
As per the heat map, Interleukin 10 was only reduced in the 350mg group and HM groups. Why? 350 was effective in activating the metabolism of fibrosis and you don't want the suppressive effects of IL-10 when you are in that mode.
1
