Possible target-related proteins of stress-resista

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Mesencephalic astrocyte-derived neurotrophic factor (Manf), is widely expressed in both neuronal and non-neuronal tissues. In the central nervous system (CNS), Manf protein expression is detected in several brain areas including the olfactory bulb, cerebral cortex, hippocampus, hypothalamus, striatum, substantia nigra (SN), and spinal cord. In the SN, Manf is detected in dopamine neurons.27 Increasing evidence indicates that Manf, when applied as extracellular proteins or delivered by viral vectors, can protect and repair midbrain dopamine neurons in vivo.28 Moreover, evidence shows that Manf is involved in the protection of existing neurons, in the regeneration of neurons and migration of newly formed neurons to the injury site in brain ischemia.29 Furthermore, as Manf localizes in the endoplasmic reticulum (ER), evidence suggests that Manf is important for the maintenance of ER homeostasis.30 Our data showed that Manf was increased in stress resilience rats compared with stress sensitive rats. This reminded us that the effect of Manf in neuron protection and ER homeostasis maintenance might be involved in the stress resilience phenotype.

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