Experimental Neurology - Available online 25 Janua
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Posted On: 02/01/2017 12:45:59 AM
Experimental Neurology - Available online 25 January 2017
Long-Term Protective Effects of AAV9-Mesencephalic Astrocyte-Derived Neurotrophic Factor Gene Transfer in Parkinsonian Rats
Highlights
• Intrastriatal delivery of AAV9-hMANF leads to robust striatal transduction.
• Intrastriatal delivery of AAV9-hMANF reduces rotational scores of parkinsonian rats.
• Intrastriatal delivery of AAV9-hMANF promotes the survival of nigral DA neurons.
• Intracellular overexpression of MANF protects SH-SY5Y cells via inhibiting ER stress.
• Extracellular rhMANF protein protects SH-SY5Y cells via the PI3K/Akt/mTOR pathway.
Abstract
Intrastriatal injection of mesencephalic astrocyte-derived neurotrophic factor (MANF) protein has been shown to provide neuroprotective and neurorestorative effects in a 6-hydroxydopamine (6-OHDA) - lesioned rat model of Parkinson’s disease.
http://www.sciencedirect.com/science/article/...861730016X
Long-Term Protective Effects of AAV9-Mesencephalic Astrocyte-Derived Neurotrophic Factor Gene Transfer in Parkinsonian Rats
Highlights
• Intrastriatal delivery of AAV9-hMANF leads to robust striatal transduction.
• Intrastriatal delivery of AAV9-hMANF reduces rotational scores of parkinsonian rats.
• Intrastriatal delivery of AAV9-hMANF promotes the survival of nigral DA neurons.
• Intracellular overexpression of MANF protects SH-SY5Y cells via inhibiting ER stress.
• Extracellular rhMANF protein protects SH-SY5Y cells via the PI3K/Akt/mTOR pathway.
Abstract
Intrastriatal injection of mesencephalic astrocyte-derived neurotrophic factor (MANF) protein has been shown to provide neuroprotective and neurorestorative effects in a 6-hydroxydopamine (6-OHDA) - lesioned rat model of Parkinson’s disease.
http://www.sciencedirect.com/science/article/...861730016X
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