Parkinson's article: "In conclusion, AAV9-mediated
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Posted On: 02/01/2017 12:27:31 AM
Parkinson's article: "In conclusion, AAV9-mediated hMANF gene transfer into the striatum exerts long-term neuroprotective and neuroregenerative effects on nigral DA neurons
against 6-OHDA-induced neurodegeneration in parkinsonian rats. Robust and stable expression of the hMANF gene seems not to have overt side effects. Activation of the PI3K/Akt/mTOR pathway and inhibition of the ER stress may constitute mechanisms underlying MANF neuroprotection for DA cells against 6-OHDA-induced toxicity. Our study supports the development of clinical trials on
MANF-based gene therapy for PD"
against 6-OHDA-induced neurodegeneration in parkinsonian rats. Robust and stable expression of the hMANF gene seems not to have overt side effects. Activation of the PI3K/Akt/mTOR pathway and inhibition of the ER stress may constitute mechanisms underlying MANF neuroprotection for DA cells against 6-OHDA-induced toxicity. Our study supports the development of clinical trials on
MANF-based gene therapy for PD"
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