sox, thanks for the outstanding explanation. Quest

sox, thanks for the outstanding explanation. Question, if the genes are turned on and functional p53 proteins are available for a short period of time, and the MDM2 complex is only briefly disrupted, what effect would you anticipate with more prolonged (continuous) exposure to Kevetrin? Perhaps the equivalent of a protective reboot? TIA and sorry for my lack of involvement earlier- long day at work...