Kevetrin does have the long lasting effect of “t

Kevetrin does have the long lasting effect of “turning on” the genes in wild type p53. The wild type p53 genes are making functional p53 proteins, but they are blocked/suppressed by the MDM2 proteins. K is small enough to get in the middle of the p53-MDM2 complex, separate the two, thus freeing the p53 protein to do its job.

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I've also wondered if the impact of Kevetrin on the cellular machinery persists well beyond what one would expect based on half lives. In that they are seeing clinical effects with a once weekly dose perhaps suggests this may be the case. I have no idea. To demonstrate clinical efficacy, however, it makes sense to maximize tumor exposure to Kevetrin.

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