26 Sep 2014 - Soluble factors for regenerative med

26 Sep 2014 - Soluble factors for regenerative medicine

We are looking for soluble factors in our body that can enhance the regeneration of damaged tissues in Wolfram syndrome and Type 1 diabetes. We have discovered two molecules so far. One of them is MANF.

We are trying to produce a large amount of these factors in the dish ( recombinant proteins ) and give these factors to animal models and cell models. We are also looking for methods/small molecules (i.e., drugs) to enhance the functions of these factors.

http://wolframsyndrome.dom.wustl.edu/soluble-...-medicine/


30 Sep 2014 - Soluble factors for regenerative medicine 3

I received another question regarding my blog of September 26, 2014.
Soluble Factors

How does MANF confer protection against ER stress-mediated cell death and stimulate proliferation of beta cells and neurons?

We are still looking for an answer. It seems like that MANF binds to another molecule in our cells and activate enzymes important for cell survival. So our strategy is to manipulate this process using a small molecule (i.e., a drug).


http://wolframsyndrome.dom.wustl.edu/soluble-...edicine-3/