Pharvaris Showcases Groundbreaking Data at Symposium
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Pharvaris Presents Key Data on Bradykinin Receptor Antagonists
At the latest Bradykinin Symposium, Pharvaris (Nasdaq: PHVS) showcased an impressive summary of data focused on its innovative oral bradykinin B2 receptor antagonists designed to effectively prevent and treat hereditary angioedema (HAE) attacks. The presentations highlighted the significant advancements in therapeutic approaches to managing this condition.
Highlighting Long-Term Efficacy of Deucrictibant
One of the featured presentations was titled Long-Term Safety and Efficacy of Oral Deucrictibant for HAE Prophylaxis, delivered by Marc A. Riedl, M.D., M.S. This analysis from the open-label extension of the CHAPTER-1 Phase 2 study revealed that treatment with deucrictibant at a dosage of 40 mg/day was well-tolerated, showing no new safety concerns. Key findings suggested:
- Continuous treatment with deucrictibant maintained the reduction in early-onset attacks observed in the placebo-controlled trial, achieving a median attack rate of zero over a year in the open-label phase.
- Participants required less than one attack treatment per year with on-demand medication, emphasizing the efficacy of deucrictibant as a preventative measure.
A Comprehensive View on Attack Management
The presentation titled Treatment of HAE Attacks with Oral Deucrictibant: RAPIDe-2 Extension Results, by Emel Aygören-Pürsün, M.D., revealed that the immediate-release capsule was safe and well-accepted across all tested doses. The findings highlighted:
- A median symptom relief onset of just 1.1 hours, with 98.5% of participants experiencing relief within 12 hours.
- The median severity reduction time was 2.6 hours, showing that 97.7% of patients achieved significant relief by the 12-hour mark.
- Remarkably, 85.8% of participants had complete resolution of their attacks within 24 hours after a single dose of the immediate-release capsule.
Improving Quality of Life for Patients
Markus Magerl, M.D., provided insights in an oral presentation about the Prophylactic Treatment with Deucrictibant Improves HAE Disease Control and HRQoL. The randomized trial showed that 90% of participants on deucrictibant reported improved disease control compared to those on placebo. This presentation included findings such as:
- Patients showed improved scores on the Angioedema Quality of Life Questionnaire (AE-QoL), specifically in areas relating to functionality and emotional well-being.
- Satisfaction levels regarding treatment effectiveness were notably higher in the deucrictibant group compared to those receiving placebo.
Comparative Effectiveness Against Standard of Care
Further discussion involved a poster presentation on Deucrictibant vs. Standard of Care in HAE: Propensity Score-Matched Analysis by Marc A. Riedl, M.D., M.S. This valuable study found that deucrictibant provided shorter relief time compared to traditional treatments, reinforcing its potential as a superior therapy for managing HAE attacks.
Exploring Cardiovascular Safety
Nieves Crespo, Ph.D., also presented findings on the cardiovascular safety of deucrictibant. Studies in non-human primate models showed no adverse effects on cardiac health after prolonged exposure to the drug, alleviating concerns regarding heart safety during HAE treatments.
Advancing Future Research
The importance of continued research was emphasized in several presentations, showcasing the utility of models like the bradykinin challenge model in humanized transgenic rats and various biomarker assays. These innovative approaches promise to enhance understanding and management of bradykinin-mediated disorders.
About Deucrictibant and Pharvaris
Deucrictibant stands out as a potent oral small-molecule bradykinin B2 receptor antagonist. By targeting bradykinin signaling, it aims to prevent HAE attacks and effectively manage symptoms when they occur. Pharvaris, as a biopharmaceutical innovator, is diligently developing advanced formulations of deucrictibant to optimize both prophylactic and on-demand therapies for HAE. Currently, they are actively enrolling participants for pivotal Phase 3 studies aimed at further validating the efficacy of deucrictibant in real-world scenarios. The commitment of Pharvaris to enhance the quality of life for individuals suffering from bradykinin-mediated angioedema remains strong.
Frequently Asked Questions
What is Pharvaris focused on developing?
Pharvaris specializes in creating novel oral bradykinin B2 receptor antagonists to treat hereditary angioedema (HAE).
What findings were presented about deucrictibant's safety?
Data indicated that deucrictibant was well-tolerated with no new safety signals, demonstrating long-term safety in patients.
How does deucrictibant impact quality of life?
Patients reported improved quality of life measures, particularly in function and emotional aspects when treated with deucrictibant.
What is the significance of the cardiovascular safety studies?
The studies showed no adverse effects on cardiac health following extended use of deucrictibant, supporting its safe profile.
What future studies is Pharvaris conducting?
Pharvaris is enrolling participants in pivotal Phase 3 studies to further assess the efficacy of deucrictibant for both prophylactic and acute treatment of HAE.
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