MannKind Discusses Afrezza Developments at International Diabetes Conference

Revolutionizing Diabetes Management with Inhaled Insulin

MannKind Corporation (Nasdaq: MNKD), recognized for its innovative approach to diabetes management, is poised to make a remarkable impact at the upcoming International Conference on Advanced Technologies and Treatments for Diabetes. The event, scheduled from March 19-22, offers MannKind a platform to present recent findings from multiple studies related to its groundbreaking inhaled insulin product, Afrezza.

Key Insights from Recent Studies

During this conference, MannKind will unveil findings based on extensive research that emphasizes the efficacy and safety of inhaled insulin. Dr. Kevin Kaiserman, Senior Vice President and Therapeutic Area Head for MannKind, expressed optimism about these studies, noting that they have spurred meaningful discussions among medical professionals regarding the use of inhaled insulin. This technology shows promise not only for adult patients but also for pediatric populations.

INHALE-1 and INHALE-3 Studies

The INHALE-1 study focuses on assessing inhaled insulin within a pediatric demographic, involving children and teenagers aged 4 to 17. This Phase 3 trial compared Afrezza with the traditional method of multiple daily injections (MDI) to improve HbA1c levels. Findings are expected to spotlight how Afrezza can transform diabetes care for younger individuals.

Simultaneously, the adult-focused INHALE-3 study builds upon this by examining the benefits of Afrezza compared to standard therapies for adults with Type 1 diabetes. This rigorous trial has yielded promising results, leading to the anticipation of a supplemental New Drug Application (sNDA) for pediatric use in the near future.

Engagement at ATTD 2025

MannKind is not just presenting data; the company is actively engaging with healthcare professionals at booth #40 of the exhibit hall. Their Clinical Education Team will be available to exchange knowledge and answer questions about Afrezza, a product that is gaining traction as a practical treatment alternative for diabetes.

Highlighted Presentations on Inhaled Insulin

Key presentations at ATTD include:

• What’s New in Pulmonary Inhaled Insulin? — Thursday, March 20, 2025, by Dr. Irl B. Hirsch
• Inhaled Insulin in Pediatrics (INHALE-1 Study) — Thursday, March 20, 2025, by Dr. Michael J. Haller
• Sustained Benefit from Inhaled Insulin in the INHALE-3 Extension Study — Saturday, March 22, 2025, by Dr. Grazia Aleppo
• Post-Prandial Glucose Excursion in Youth vs. Adults (INHALE-1 Study) — Saturday, March 22, 2025, by Dr. Michael J. Haller
• Comparison of Inhaled Technosphere Insulin Plus Insulin Degludec Versus Usual Care — Saturday, March 22, 2025, by Dr. Anastasios Manessis

These presentations promise to shed light on the ongoing advancements and the potential of inhaled insulin in managing diabetes more effectively.

Understanding Afrezza and Its Impact

Afrezza is a revolutionary rapid-acting inhaled insulin that enhances glycemic control for adults living with diabetes. Notably, it offers a unique delivery method that addresses the needs of patients who often face challenges with traditional insulin administration methods.

Safety and Efficacy Considerations

MannKind emphasizes that while Afrezza shows significant advantages, it is essential for potential users to be aware of its limitations, including contraindications in patients with chronic lung diseases such as asthma and COPD. Comprehensive medical evaluations are crucial when considering Afrezza to ensure patient safety.

The continual development of Afrezza reflects MannKind’s commitment to innovate within the diabetes management landscape. With the integration of patient feedback and clinical evidence, MannKind is refining the way insulin therapy is administered, making it more user-friendly and accessible for patients.

About MannKind Corporation

MannKind Corporation is dedicated to addressing severe unmet medical needs for individuals suffering from diabetes and other pulmonary conditions. The company’s advanced technologies in drug formulation and delivery are designed to improve patient outcomes and offer greater independence in managing health. Emphasizing a patient-centric approach, MannKind continues to pursue innovations that enhance the quality of life for those affected by diabetes.

Frequently Asked Questions

What is Afrezza?

Afrezza is a rapid-acting inhaled insulin designed to help manage blood sugar levels in adults with diabetes.

How does Afrezza compare to traditional insulin therapies?

Afrezza offers a convenient inhaled delivery method that may improve patient compliance compared to multiple daily injections.

What are the recent findings from the INHALE studies?

The studies indicate that Afrezza is effective and safe for both pediatric and adult patients, with ongoing research supporting its use.

Where will MannKind showcase its research?

MannKind will present its research findings at the ATTD Conference in Amsterdam.

Can Afrezza be used in all diabetes patients?

Afrezza is not recommended for patients with chronic lung conditions and requires medical evaluation before use.

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