Innovative Weight Loss Breakthrough from Ascletis Pharma

Ascletis Unveils Promising Results in Weight Loss Research

Ascletis Pharma Inc. has recently announced exciting preclinical efficacy results from their research into ASC47 and ASC31, marking a significant step forward in innovative treatment options for obesity. In this study involving a diet-induced obesity (DIO) mouse model, the combination of a low dose of ASC47 and ASC31 resulted in an impressive 44.8% reduction in body weight after just 14 days.

Groundbreaking Combination of ASC47 and ASC31

The compelling data reveals that this combination not only led to substantial weight loss but also significantly outperformed the alternative pairing of ASC47 with tirzepatide, yielding a weight reduction of 44.8% compared to 38.1%. These findings underscore the unique benefits of combining these innovative therapies.

ASC31: A Novel Peptide Agonist

ASC31 is an intriguing addition to Ascletis's portfolio, designed as a dual GLP-1 and GIP peptide agonist. Early studies indicate that ASC31 possesses favorable pharmacokinetic properties and exhibits promising in vitro activities as well as efficacy in vivo with DIO mouse models. This peptide agonist exemplifies Ascletis's commitment to using its Ultra-Long-Acting Platform (ULAP) to develop advanced therapeutics.

Insights into ASC47's Unique Mechanism

Meanwhile, ASC47 stands out as a thyroid hormone receptor beta (THR?) selective small molecule agonist, initially discovered and developed within Ascletis. Its adipose-targeting properties allow for increased concentrations of the drug within fat tissue, a characteristic that could potentially lead to more effective weight management.

Results of the DIO Mouse Study

The recent DIO mouse study aimed to directly compare the weight loss efficacy of ASC47 combined with ASC31 against ASC47 combined with tirzepatide. The results were telling; the ASC47 and ASC31 combination resulted in a reduction in body weight that was statistically significant. The 17.6% increase in efficacy compared to tirzepatide (p=0.02) suggests that this combination may provide a meaningful alternative in the obesity treatment landscape.

Company Vision for Obesity Treatment

Dr. Jinzi Jason Wu, the Founder, Chairman, and CEO of Ascletis, expressed optimism regarding the implications of these results, stating that the combination of ASC47 and ASC31 could offer valuable differentiation from currently available obesity treatments. He emphasized Ascletis's ongoing development of a robust pipeline aimed at addressing obesity through small molecules and peptides.

About Ascletis Pharma Inc.

Ascletis Pharma Inc. is an integrated biotechnology company specializing in the development and commercialization of cutting-edge therapeutics aimed at treating metabolic diseases. They leverage their proprietary Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD) Platform alongside their Ultra-Long-Acting Platform (ULAP) to advance their research. ASC30, their leading drug candidate, is being developed both as a once-daily oral tablet and a once-monthly injectable for effective weight management.

Frequently Asked Questions

What is the main focus of Ascletis Pharma?

Ascletis Pharma is focused on developing innovative treatments for metabolic diseases, including obesity.

What are ASC47 and ASC31?

ASC47 is a thyroid hormone receptor beta selective small molecule, while ASC31 is a novel peptide agonist targeting GLP-1 and GIP receptors.

How effective is the combination of ASC47 and ASC31?

This combination showed a 44.8% reduction in body weight in a study compared to 38.1% with tirzepatide.

What differentiates ASC31 from other treatments?

ASC31 utilizes a dual mechanism by targeting both GLP-1 and GIP receptors, which may provide enhanced weight loss results.

How does Ascletis aim to tackle obesity?

Ascletis plans to address obesity through a pipeline of advanced small-molecule and peptide therapeutics designed for effective weight management.

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