Innovative Trial Results Show Promise for Soft Tissue Sarcoma

Exciting Developments in Cancer Treatment Presented at CTOS 2024

In an enlightening presentation at the CTOS 2024 Annual Meeting, substantial progress in the treatment of soft tissue sarcoma was shared, showcasing the impressive outcomes of the EFTISARC-NEO trial. This clinical investigation evaluates the use of eftilagimod alpha (efti) combined with pembrolizumab and radiotherapy. The results indicate a marked improvement in patient response compared to traditional therapies.

Remarkable Efficacy Observed with New Treatment Combination

Data revealed a significant increase in tumor hyalinization, a primary endpoint of this study, which stands as a critical indicator of overall survival rates. The therapy achieved over a three-fold increase in tumor hyalinization when compared to results obtained with standard radiotherapy alone. This vital finding emphasizes the potential impact of this innovative approach on treatment outcomes for patients facing this aggressive disease.

Key Insights from Lead Investigators

The trial’s principal investigators, Dr. Katarzyna Kozak and Dr. Pawe? Sobczuk, expressed their confidence in efti’s unique capability in enhancing the efficacy of combined treatments. They noted that the synergy of eftilagimod with radiotherapy and pembrolizumab has the potential to redefine how soft tissue sarcoma is treated, which is essential, given the limited options currently available for patients.

Elevated Pathologic Responses and Safety Profile

The interim results from 21 patients indicated that 71.4% of participants exhibited a pathologic response characterized by a hyalinization rate of 35% or higher. This statistic, coupled with no reported grade 3 or higher toxicities from the combined therapy, highlights both the treatment's efficacy and its safety. As Dr. Frédéric Triebel, CSO of Immutep, pointed out, these preliminary results are promising and suggest strong potential across various soft tissue sarcoma subtypes.

Ongoing Study Plans and Future Directions

The ongoing Phase II study, set against a backdrop of evolving therapeutic strategies, aims to enroll 40 patients by early next year. Being primarily funded by an approved grant from the Polish government through the Polish Medical Research Agency program, this trial is poised to explore deeper into the benefits of the triple combination therapy.

Company Background: Immutep’s Commitment to Innovation

Immutep Limited (NASDAQ: IMMP; AUST: IMM.AX), as a pioneering clinical-stage biotechnology enterprise, focuses on advancing LAG-3 immunotherapies tailored for cancer and autoimmune diseases. Their research initiatives and product developments reflect a commitment to improving patient health and enhancing survival rates through innovative treatments. Their work is pivotal in transforming the landscape of therapeutic options available to patients.

For anyone interested in these developments, more details can be explored on Immutep’s official website.

Frequently Asked Questions

What results were presented at the CTOS 2024 Annual Meeting?

The results of the EFTISARC-NEO trial showed that combining eftilagimod alpha, pembrolizumab, and radiotherapy significantly increased tumor hyalinization in soft tissue sarcoma patients.

How does tumor hyalinization affect patient survival?

Tumor hyalinization is an important predictor of overall survival in patients with soft tissue sarcoma, indicating how well a patient may respond to treatment.

What percentage of patients responded positively to the treatment?

In the trial, 71.4% of patients achieved a pathologic response defined as having 35% or more hyalinization.

What safety concerns were noted in the trial?

There were no grade 3 or higher toxicities reported linked to the combination therapy, indicating a favorable safety profile.

What is Immutep’s focus as a company?

Immutep is dedicated to developing innovative LAG-3 immunotherapies aimed at treating cancer and autoimmune diseases, leveraging their expertise in immune response modulation.

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