Dr. Iwasaki Joins Invivyd's SPEAR Group for Long COVID Research

Dr. Akiko Iwasaki Joins Invivyd's SPEAR Study Group

Invivyd, Inc. (Nasdaq: IVVD), based in Waltham, Massachusetts, is making strides in understanding Long COVID and COVID-19 Post-Vaccination Syndrome (PVS) through its innovative SPEAR Study Group. Recently, the company has welcomed Dr. Akiko Iwasaki, a prominent figure in immunobiology from Yale School of Medicine, to its research efforts.

The SPEAR initiative, which stands for Spike Protein Elimination and Recovery, aims to delve into the biological implications and clinical aspects of lingering symptoms associated with the spike protein from the SARS-CoV-2 virus and its corresponding vaccines. Dr. Iwasaki, an expert in viral pathogenesis and chronic post-viral conditions, brings significant insights into the dynamic landscape of immune responses observed post-vaccination and in Long COVID patients.

Understanding Long COVID and COVID-19 PVS

Long COVID refers to the prolonged symptoms experienced by individuals recovering from COVID-19. These can include fatigue, cognitive difficulties, and respiratory issues. PVS, on the other hand, characterizes the ongoing health challenges some individuals face after receiving a COVID-19 vaccine. The contribution of persistent SARS-CoV-2 spike protein in sustaining these symptoms is an area of active investigation. Dr. Iwasaki’s leadership in studies like the Yale COVID-19 Recovery Study advance our understanding of these complexities.

As the Co-Lead Investigator, Dr. Iwasaki’s research focuses on how vaccination can change immune responses for those suffering from Long COVID. Her ongoing studies have been pivotal in analyzing how the body reacts to the residual effects of the virus, shaping new treatment pathways and therapeutic explorations.

Invivyd's Commitment to Research and Treatment

Marc Elia, the Chairman of the Board at Invivyd, expressed enthusiasm about Dr. Iwasaki's addition to the team, noting the exceptional value her expertise brings. With millions still grappling with the enduring consequences of COVID-19, Invivyd is dedicated to leveraging cutting-edge monoclonal antibody technologies to offer genuine therapeutic options.

The SPEAR Group has been formed in light of various reports suggesting patients with Long COVID may experience improvements following the administration of PEMGARDA, a monoclonal antibody authorized by the U.S. FDA for select immunocompromised populations. Though currently not authorized for Long COVID treatment, the emerging anecdotal evidence reinforces the hypothesis that spike proteins or remnants of the virus could be significant therapeutic targets.

Research Initiatives: SPEAR and Beyond

The SPEAR Study Group plans to rigorously explore the safety and efficacy of monoclonal antibody treatments for Long COVID and PVS. By collaborating on clinical trials, the group aims to uncover vital data that could transition into effective treatment protocols, benefitting individuals struggling with these conditions.

Moreover, Invivyd is also advancing its investigational monoclonal antibody candidate, VYD2311, intended to address COVID-19 needs with improved delivery methods and enhanced patient experiences. This next-generation antibody is part of Invivyd's ongoing efforts to innovate and optimize therapeutic options against COVID-19.

PEMGARDA and Its Role in COVID-19 Treatment

PEMGARDA (pemivibart), another key player in Invivyd's therapeutic lineup, represents an advanced monoclonal antibody targeting the SARS-CoV-2 spike protein. While it shows promise for pre-exposure prophylaxis in specific high-risk populations, it is crucial to note that PEMGARDA is not authorized for treating Long COVID itself.

The development of such monoclonal antibodies exemplifies Invivyd's commitment to protect public health against serious viral threats. Ongoing studies will help to flesh out the potential uses of these treatments, and the company remains focused on evolving its research based on emerging data and patient needs.

About Invivyd, Inc.

Invivyd, Inc., recognized for its biopharmaceutical innovation, aims to deliver robust protection against serious viral infections, starting with SARS-CoV-2. Utilizing a proprietary technology platform, Invivyd continues to assess and develop state-of-the-art antibodies tailored to the current challenges posed by evolving viruses. With a monitoring and adaptive approach, the company is poised to make significant contributions to the field of infectious disease treatment.

For more detailed information, you can visit the official Invivyd website, where further insights into their research and available products can be obtained.

Frequently Asked Questions

What is the purpose of the SPEAR Study Group?

The SPEAR Study Group focuses on studying the biology and clinical implications of spike proteins associated with Long COVID and COVID-19 PVS.

What is Dr. Iwasaki's role in this initiative?

Dr. Akiko Iwasaki serves as a co-Lead Investigator, contributing her expertise in viral pathogenesis and immunobiology to the research efforts.

What is PEMGARDA, and what is its purpose?

PEMGARDA is a monoclonal antibody intended for the pre-exposure prevention of COVID-19 in certain immunocompromised patients but is not authorized for Long COVID treatment.

How does Invivyd plan to use antibodies in its research?

Invivyd aims to assess the safety and exploratory efficacy of monoclonal antibodies in clinical trials to treat Long COVID and PVS, utilizing innovative candidates like VYD2311.

Where can I find more information about Invivyd's products?

Further information about Invivyd's products and research can be found on their official website.

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