CARsgen Reports Promising Long-term Findings for Zevor-cel Use
CARsgen Highlights Long-term Outcomes for Zevor-cel at IMS Event
CARSgen Therapeutics Holdings Limited (Stock Code: 2171.HK) is excited to share the updated long-term follow-up results from the Phase I clinical trial of zevorcabtagene autoleucel, commonly referred to as zevor-cel. This innovative CAR T-cell therapy, which targets BCMA, was showcased during a significant conference, the 22nd International Myeloma Society Annual Meeting, through an engaging poster presentation.
Significant Findings from the Clinical Study
A total of 14 patients diagnosed with relapsed or refractory multiple myeloma (R/R MM) participated in this impactful trial. These patients received a single infusion of zevor-cel, allowing researchers to track their progress closely. By mid-2025, the follow-up period had reached an impressive median of 53.3 months, demonstrating the potential durability of this treatment.
Safety Profile of Zevor-cel
Safety remains a crucial factor in any treatment. Throughout the trial, no participants reported any instances of significant cytokine release syndrome (CRS) or immune effector cell-associated neurotoxicity syndrome (ICANS). Additionally, there were no reports of other serious delayed adverse events like second primary malignancies. This excellent safety profile is encouraging for future patient outcomes.
Efficacy Observed with Zevor-cel Treatment
The results highlighted in the study reveal a remarkable overall response rate of 100%, underscoring zevor-cel's effectiveness. Out of the 14 patients, 11 achieved a complete response (CR) or a stringent complete response (sCR), and notably, all patients who reached CR or better were declared minimal residual disease (MRD) negative. One participant maintained their sCR status for a lengthy 59.3 months.
Long-Term Impact on Patient Survival Rates
The analysis also recorded statistics that are crucial in cancer treatments. The median progression-free survival (mPFS) for those achieving CR/sCR was 44.1 months, while the median duration of response (mDoR) stood at 43.2 months. The overall survival rate has proven to be promising, with 100% of patients alive at 24 months, and 76.9% remained at 60 months following the infusion.
Insight into Zevor-cel
Zevor-cel is a state-of-the-art, fully human autologous BCMA CAR T-cell product tailored for the treatment of Multiple Myeloma. It received approval following its evaluation by health authorities, offering hope to adults battling R/R MM who have exhausted previous therapies.
About CARsgen Therapeutics Holdings Limited
CARsgen is at the forefront of biopharmaceutical innovation, focusing on groundbreaking CAR T-cell therapies. Their mission revolves around addressing significant clinical needs in areas such as hematologic malignancies, solid tumors, and autoimmune conditions. The company's capabilities span across the entire CAR T-cell process, from research and development to clinical applications and large-scale production.
Through cutting-edge technologies and a robust product pipeline, CARsgen strives to overcome existing challenges faced by current CAR T-cell treatments, aiming to elevate safety standards, improve efficacy, and reduce overall treatment costs.
Frequently Asked Questions
What are the main findings from the CARsgen study on zevor-cel?
The study revealed a 100% overall response rate, with many patients achieving complete or stringent complete responses and maintaining these for extended periods.
How long was the follow-up period for patients treated with zevor-cel?
Patients in the study had a median follow-up duration of 53.3 months, highlighting the long-term impacts of the treatment.
What safety concerns were reported during the zevor-cel trial?
No significant safety issues such as Grade 3 CRS or ICANS were reported, indicating a strong safety profile for zevor-cel.
What distinguishes zevor-cel from other treatments?
Zevor-cel is a fully human, autologous CAR T-cell therapy specifically targeting BCMA in multiple myeloma patients, focusing on personalized treatment.
What is the mission of CARsgen Therapeutics?
CARsgen aims to be a leader in biopharmaceuticals, producing innovative therapies for global patients, particularly in oncology and beyond.
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