Vidac Pharma Secures Patent, Enhancing Oncology Treatment Innovations

Vidac Pharma's Groundbreaking Patent Announcement

Vidac Pharma Holdings Plc, a pioneering clinical-stage biopharmaceutical company, has made a significant stride in oncology with the recent issuance of a patent by the United States Patent and Trademark Office (USPTO). This patent provides extensive protection for the innovative mode of action underlying the company's oncology and onco-dermatologic drug candidates.

Understanding the Mode of Action

The patent secures the use of Vidac's novel chemical entities designed to disrupt the hexokinase 2 isozyme's role in cancer metabolism. By detaching hexokinase 2 from the mitochondrial voltage-dependent anion channels (VDAC pores), Vidac's approach aims to reverse the hyperglycolytic metabolism that is prevalent in cancer cells. This has been shown to halt cancer cell proliferation, restore apoptosis, and counteract the immunosuppressive environment that typically supports tumor growth.

CEO's Perspective on the Patent

In light of this development, Prof. Max Herzberg, Chief Executive Officer of Vidac Pharma, expressed his excitement, stating, "This extremely wide-ranging patent is very welcome news for Vidac, given that it provides full protection of our efforts to bring an entirely new class of cancer treatments to market." He highlighted that Vidac is unique in its approach to reversing the Warburg effect, a metabolic hallmark of cancer cells, thus underscoring the patent's significance in the U.S. market.

Product Candidates and Their Impact

Vidac Pharma is advancing two product candidates, namely VDA-1275 and VDA-1102. Both candidates work by inhibiting the interaction between hexokinase 2 and VDACs, which plays a critical role in cancer metabolism. Cancer cells tend to overexpress HK2, a factor that catalyzes glucose metabolism and, consequently, fuels tumoral growth. By blocking VDAC channels, HK2 facilitates anti-apoptotic signals, enhancing survival for cancer cells and promoting an acidic tumor microenvironment.

Clinical Studies and Efficacy

The clinical studies conducted for Vidac's initial metabolic checkpoint modulators have showcased promising results, effectively halting the growth of cancer cells and restoring immune sensitivity and programmed cell death. Currently, VDA-1102 is under Phase 2b clinical studies for treating advanced actinic keratosis and is also being assessed in Phase 2 trials for cutaneous T-cell lymphoma.

Combination Therapy Potential

In addition to its standalone efficacy, VDA-1275 has demonstrated significant results when combined with established cancer therapies, including sorafenib and cisplatin. Notably, animal studies revealed that VDA-1275 could trigger its own immunological response, promoting the formation of anti-tumor macrophages and memory T-cells, thereby inhibiting tumor-promoting macrophages and supporting a healthier immunological environment.

About Vidac Pharma

Vidac Pharma is dedicated to the discovery and development of first-in-class medicines focusing on oncologic and onco-dermatologic diseases. The company aims to provide innovative drug solutions that target metabolic checkpoints in cancer cells, promoting their programmed death while preserving healthy tissue. With its leading product candidate, VDA-1102, Vidac seeks to address significant unmet needs in the treatment of advanced actinic keratosis and cutaneous T-cell lymphoma.

Contact Information

For more information, you may contact Dr. Max Herzberg at Vidac Pharma Holdings Plc, located at 20-22 Wenlock Road, London N1 7GU, United Kingdom. For inquiries, you can reach +972-54-4257381 or +972-77-9300647.

Frequently Asked Questions

What is the significance of Vidac Pharma's new patent?

The patent grants Vidac Pharma extensive protection for its innovative approach to oncology treatment, particularly against the hyperglycolytic metabolism of cancer cells.

What are the primary product candidates developed by Vidac Pharma?

Vidac's primary product candidates are VDA-1275 and VDA-1102, which target hexokinase 2 and VDACs in cancer cells to halt growth and restore normal cell death processes.

How does VDA-1102 impact cancer treatment?

VDA-1102 shows promise in clinical studies for advanced actinic keratosis and cutaneous T-cell lymphoma, offering a potential new therapeutic option for patients.

What is the unique approach Vidac Pharma is taking?

Vidac Pharma focuses on reversing the Warburg effect in cancer cells, a unique approach that sets them apart in developing cancer therapies.

Who can be contacted for more information about Vidac Pharma?

Interested individuals can reach out to Dr. Max Herzberg at Vidac Pharma's London office for more information on the company's initiatives and drug candidates.

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