Vera Therapeutics to Present Key Findings on Atacicept at ASN
Exciting Developments from Vera Therapeutics
Vera Therapeutics, Inc. (NASDAQ: VERA), a pioneering biotechnology company in the clinical stage, focuses on creating impactful treatments for severe immunological ailments. They have exciting news to share regarding their latest clinical trial outcomes!
Key Insights from the ORIGIN Trial
The ORIGIN Phase 3 trial explored the effects of atacicept, aimed at treating IgA nephropathy (IgAN). This important study will be highlighted during the opening plenary session of the American Society of Nephrology (ASN) Kidney Week 2025, set to take place soon. This platform will allow Vera to present groundbreaking information regarding their work in this critical area.
Presentation Details
The featured late-breaking oral presentation scheduled is titled "ORIGIN 3: A Phase 3 Trial of Atacicept in IgAN". Renowned expert Richard Lafayette, MD, FACP, who is a Professor of Medicine (Nephrology) and Director of the Glomerular Disease Center at Stanford University Medical Center, will lead the discussion. This session will occur on Thursday morning from 9:02 AM to 9:14 AM CST, with an abstract numbered TH-OR083.
About Atacicept and Its Development
Atacicept is an innovative investigational fusion protein. Its mechanism involves binding to key cytokines like B-cell activating factor (BAFF) and A proliferating Ligand (APRIL). These components play a crucial role in B-cell survival and the development of autoantibodies, which are significant in diseases like IgAN.
Clinical Trial Efficacy
The robust outcomes from the ORIGIN Phase 2b trial were promising. They demonstrated notable decreases in proteinuria and stabilization of eGFR when compared with placebo over 36 weeks. Results also indicated that atacicept maintained a favorable safety profile, indicating its potential as a leading treatment option.
Vera’s Commitment to Innovation
Vera Therapeutics is committed to pushing forward with atacicept, showcasing its best-in-class potential after receiving FDA Breakthrough Therapy Designation. This designation underscores the belief that atacicept may significantly improve treatment outcomes for patients affected by IgAN compared to existing therapies.
Continuous Developments
The ORIGIN Extend study is providing invaluable data on atacicept, capturing vital long-term safety and effectiveness feedback while providing participants extended access. Meanwhile, further research is underway, looking into using atacicept across various autoimmune diseases beyond IgAN.
Further Information about Vera Therapeutics
Vera Therapeutics is unwavering in its mission to transform treatment landscapes for immune-mediated diseases. Their lead candidate, atacicept, is designed for self-administration at home once per week, reflecting a significant move towards patient-centric care. The company also holds an exclusive license for a new fusion protein VT-109 and is developing MAU868, targeting BK virus infections, especially in kidney transplant recipients. This aligns perfectly with their broader strategy to tackle multiple disease areas effectively.
Frequently Asked Questions
What is the ORIGIN trial about?
The ORIGIN trial examines the efficacy of atacicept in treating IgA nephropathy (IgAN), showcasing encouraging results in improving patient outcomes.
Who will present at ASN Kidney Week 2025?
Richard Lafayette, MD, a key figure in nephrology, will present the findings from the ORIGIN trial.
What is atacicept?
Atacicept is an investigational drug that inhibits key signaling pathways in B-cells, which are involved in conditions like IgAN and lupus nephritis.
What is Vera Therapeutics' focus?
Vera Therapeutics aims to develop innovative therapies for serious immunological diseases, improving patient care and treatment standards.
How does the ORIGIN Extend study benefit patients?
The ORIGIN Extend study allows participants ongoing access to atacicept, gathering crucial long-term efficacy and safety data as they await its commercial availability.
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