Vera Therapeutics Announces Upcoming Webcast on ORIGIN 3 Trial

Investor Call and Webcast Announcement

BRISBANE, Calif. — Vera Therapeutics, Inc. (Nasdaq: VERA), a biotechnology firm devoted to innovative treatments for serious immunological diseases, has announced a forthcoming investor call and webcast scheduled for November 6, 2025, at 4:30 PM ET. This event will spotlight the preliminary outcomes from the ORIGIN Phase 3 clinical trial of atacicept, aimed at treating IgA nephropathy (IgAN), which will be showcased at a primary session during an eminent medical conference. The company invites participants to review the significant findings that reflect their commitment to advancing patient care.

What to Expect During the Webcast

The presentation will feature insights from esteemed experts such as Dr. Jonathan Barratt, a leading figure in renal medicine at the University of Leicester, and Dr. Richard Lafayette of Stanford University, who bring extensive knowledge and experience in nephrology. Following the detailed presentation, a live question-and-answer segment will allow investors to engage directly with the speakers, enhancing the overall transparency and accessibility of the information shared.

About Dr. Jonathan Barratt

Dr. Barratt specializes in IgAN and leads a prominent research group within the University of Leicester’s College of Life Sciences. With a strong focus on translating research into effective treatments, his work includes leading numerous international clinical trials aimed at finding improvement strategies for this debilitating condition. Dr. Barratt also contributes to multiple organizations, actively collaborating with pharmaceutical companies to enhance treatment methodologies.

About Dr. Richard Lafayette

As Director of the Stanford Glomerular Disease Center, Dr. Lafayette is renowned for his profound understanding of nephrology and glomerular diseases. His distinguished career encompasses substantial educational efforts and board memberships in leading nephrology communities, alongside significant contributions to various clinical trials and research projects focused on enhancing patient outcomes in kidney health.

Insights into Atacicept

Atacicept is an investigational fusion protein designed to inhibit BAFF and APRIL, cytokines crucial in the regulation of B-cell survival. Elevated levels of these cytokines are often associated with the progression of conditions like IgAN and lupus nephritis, making atacicept a promising candidate in kidney disease management. This therapy showcases the potential for innovation in tackling complex immunological disorders.

Get Updates on the ORIGIN Clinical Program

The ORIGIN Phase 2b study has produced encouraging results, achieving both primary and secondary endpoints. Participants demonstrated significant reductions in proteinuria and stabilization of kidney function. Safety assessments revealed a comparable profile between atacicept and placebo, contributing to a robust basis for ongoing clinical development. This success positions Vera Therapeutics as a leader in the evolving landscape of immunological therapies.

Future Directions for Atacicept

Atacicept's designation as a Breakthrough Therapy by the FDA underlines its potential to outperform existing treatment options for IgAN. The ORIGIN trial's results indicate that Vera Therapeutics not only leads in research but also embodies a transformative approach in patient care by ensuring that innovative treatments reach those in need. The company is actively exploring the long-term effectiveness of atacicept through the ORIGIN Extend study, providing participants with continued access to the treatment.

About Vera Therapeutics

Vera Therapeutics is dedicated to revolutionizing care for patients with immunological diseases through groundbreaking therapies. Its flagship product, atacicept, is designed to address the underlying causes of diseases like IgAN. As the company explores additional areas where reducing autoantibodies can have significant benefits, it continues to uphold its mission of transforming standards of care and expanding its development pipeline with innovative treatments like VT-109 and MAU868.

Frequently Asked Questions

What is the focus of Vera Therapeutics?

Vera Therapeutics primarily focuses on developing innovative treatments for serious immunological conditions, aiming to improve patient outcomes significantly.

What is the ORIGIN trial about?

The ORIGIN trial investigates the efficacy of atacicept in treating IgA nephropathy, aiming to assess its impact on kidney function and related symptoms.

Who are the experts participating in the upcoming webcast?

Dr. Jonathan Barratt and Dr. Richard Lafayette, both renowned nephrologists, will participate in the webcast to provide insights into the ORIGIN trial outcomes.

What is atacicept?

Atacicept is a novel investigational drug aimed at reducing the activity of specific cytokines involved in autoimmune diseases, particularly focusing on IgAN and lupus nephritis.

How can I stay updated on Vera Therapeutics’ developments?

Interested individuals can frequently check the Vera Therapeutics official website for updates on clinical trials, new studies, and additional company news.

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