Umecrine Cognition Reports Positive Study Results for Golexanolone
Umecrine Cognition Showcases Key Findings from Clinical Study
Karolinska Development AB (NASDAQ: KDEV) has exciting news to share regarding its portfolio company, Umecrine Cognition. The latest interim analysis from an ongoing Phase 1b/2a clinical trial has provided promising data about golexanolone, a novel drug targeting cognitive symptoms in patients suffering from Primary Biliary Cholangitis (PBC). The findings reveal that golexanolone has been well-tolerated among participants, achieving drug exposure levels consistent with therapeutic dosages.
Insights on the Clinical Trial
The recent study focused on a group of patients who experience significant fatigue and cognitive issues due to PBC. Golexanolone, administered in a regimen of 40 mg taken twice daily, has shown encouraging results. Among eight patients involved in the initial phase of the study, only mild adverse effects were observed, indicating a favorable safety profile for this medication. Furthermore, after just five days of treatment, patients exhibited clinically relevant steady-state drug exposure levels.
Focus on Patient Wellness
The interim results also highlighted marked improvements in anxiety and depression scores, backing the effectiveness of golexanolone not just as a treatment for fatigue, but also as a potential remedy for cognitive impairments. The next steps in this clinical research, which will involve 84 additional PBC patients, aim to investigate the drug’s pharmacological properties and its efficacy in alleviating cognitive symptoms and fatigue.
CEO's Statement on Study Progress
Viktor Drvota, CEO of Karolinska Development, expressed excitement regarding the findings presented by Umecrine Cognition. He emphasized the significance of these results and their contributions to understanding the safety and efficacy of golexanolone. Drvota stated, “We are delighted to see these important new data from our portfolio company, reaffirming the promising safety profile of golexanolone.”
Expert Presentation of Findings
The results from the interim analysis will be shared by Professor David E. Jones, who serves as the Principal Investigator in the clinical study. His presentation is scheduled for the Late Breaking Posters session at an upcoming medical conference, where attendees are expected to gain insights into the trial's findings.
Karolinska Development’s Commitment
Karolinska Development's investment in Umecrine Cognition represents a significant 73% ownership. This strong affiliation underscores their commitment to advancing medical innovation and supporting the development of therapies that address unmet medical needs. Karolinska Development is dedicated to fostering companies that enhance patient outcomes through innovative treatments.
About Karolinska Development
Karolinska Development AB is a leading life sciences investment firm in the Nordic region, focused on translating scientific advancements into practical medical solutions. By collaborating with innovative entrepreneurs and leveraging world-class research from the Karolinska Institutet and other prestigious institutions, the company aspires to develop breakthrough therapies.
Frequently Asked Questions
What is golexanolone?
Golexanolone is an investigational drug designed to alleviate cognitive symptoms in patients with liver diseases, particularly those suffering from Primary Biliary Cholangitis.
What were the results of the interim analysis?
The interim analysis indicated that golexanolone was well-tolerated, with only mild side effects, and achieved drug exposure levels that are consistent with clinical treatment doses.
How many patients were involved in the study?
The first part of the study involved eight patients, with plans to expand the research to 84 evaluable patients for further investigation.
What are the aims of the ongoing clinical study?
The ongoing study aims to confirm golexanolone's pharmacological profile and evaluate its efficacy in improving cognitive symptoms and fatigue in patients with Primary Biliary Cholangitis.
Who is leading the clinical study?
Professor David E. Jones, the Principal Investigator, is leading the clinical study, and he will present the findings at the Late Breaking Posters session of an upcoming medical meeting.
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