TriSalus Life Sciences Reveals Breakthrough in Tumor Treatment
Innovative Advances in Cancer Treatment by TriSalus Life Sciences
TriSalus Life Sciences®, Inc. (Nasdaq: TLSI) is taking significant strides in oncology by enhancing the delivery of therapies directly to liver and pancreatic tumors. With their innovative Pressure-Enabled Drug Delivery™ (PEDD™) technique via the TriNav® Infusion System, recent research published underscores improved therapeutic efficacy compared to traditional methods. The pivotal study published in the Journal of Vascular and Interventional Radiology showcases the remarkable capacity of the PEDD method to enable deeper penetration of glass microspheres (GM) into solid tumors.
The Study and Its Implications
The published research, titled “Intra-arterial Pressure-Enabled Drug Delivery Significantly Increases Penetration of Glass Microspheres in a Porcine Liver Tumor Model,” demonstrates significant improvements in treatment delivery. Conducted in a transgenic (oncopig) model, the study found that utilizing the PEDD approach not only enhanced the delivery of glass microspheres but also allowed for a more effective targeting of tumor tissues compared to traditional microcatheters.
Dr. Bryan F. Cox, TriSalus's Chief of Research, expressed excitement over these findings, noting, “This is another example of how our PEDD approach effectively tackles a significant challenge in cancer care by ensuring the selective and increased delivery of therapeutics to the tumor.” The research illustrates not just improved delivery rates but also the potential for more strategic treatment applications, targeting multiple tumors in patients with extensive disease burdens.
Enhancing Safety and Efficacy
Mary Szela, the CEO of TriSalus, reiterated the substantial enhancements made possible through the PEDD method. She stated, “Efficient delivery of therapeutics into tumor cells without causing harm to off-target normal tissue remains a real-world challenge in cancer care, and the PEDD approach aims to overcome this obstacle.” This improved method signifies hope for patients dealing with complex liver and pancreatic tumors, highlighting the importance of innovative approaches in modern medicine.
In fact, the study's findings suggest that the novel PEDD technique could replicate the safety profile observed in selective Y90 treatments, which are standard for more advanced diffuse disease scenarios. This potential means that efficacy can be achieved without compromising patient safety, paving the way for more effective cancer management strategies.
Research Overview and Key Findings
The research conducted involved transgenic pigs and measured the impact of different infusion methods on tumor treatment delivery. Using near-infrared imaging to track GM fluorescent signals, the results revealed a 117% increase in tumor penetration through lobar infusions using the PEDD method, alongside a 39% increase when using selective infusions. These findings not only serve as high-resolution evidence of enhanced delivery, but they also stress the vital role of innovation in addressing significant challenges in cancer therapy.
The comparison highlighted that the lobar PEDD delivery of GM was statistically equivalent to conventional selective delivery methods, marking a crucial step forward in treatment methodologies.
About TriSalus Life Sciences
TriSalus Life Sciences® is pioneering drug delivery technologies aimed at transforming the treatment landscape for liver and pancreatic cancers. Their platform includes advanced devices like the TriNav® Infusion System, which leverages PEDD to improve therapy delivery while minimizing normal tissue damage. The commitment of TriSalus to innovation is evident through their partnerships with leading cancer centers across the nation, pushing the boundaries of medical technology and enhancing patient outcomes.
Through the utilization of their investigational immunotherapy candidate, nelitolimod, TriSalus is also tackling the immunosuppressive environments generated by tumors, which often render existing therapies less effective. Their clinical trials signal exciting preliminary results supporting the usage of nelitolimod via PEDD in overcoming delivery barriers within the complex liver and pancreas anatomy.
TriSalus aims to provide meaningful improvements in patient care through the responsive development of their therapies, reflecting a deep commitment to oncology advancement.
Frequently Asked Questions
What is the PEDD method?
The Pressure-Enabled Drug Delivery (PEDD) method enhances the delivery of therapeutics by modulating pressure and flow to achieve deeper penetration into tumors while minimizing damage to surrounding normal tissues.
How does the TriNav® Infusion System work?
The TriNav® Infusion System is designed to optimize drug delivery to liver tumors, leveraging the PEDD approach for more effective treatment results.
What were the key findings of the recent research study?
The research demonstrated significant increases in the penetration of glass microspheres into liver tumors, highlighting a 117% improvement with lobar infusions using the PEDD method compared to conventional techniques.
Who benefits from these advancements?
Patients suffering from liver and pancreatic tumors stand to gain significantly from the enhanced efficacy and safety profiles proposed by TriSalus Life Sciences' innovative delivery methods.
What goals does TriSalus Life Sciences aim to achieve?
TriSalus is focused on improving therapeutic delivery systems in oncology, enhancing patient outcomes, and advancing research to address the barriers presented in tumor treatment.
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