Tempest Therapeutics Soars on New Phase 3 Liver Cancer Study
Tempest Therapeutics Stock Rises on Promising Liver Cancer Research
Tempest Therapeutics Inc. (NASDAQ: TPST) is experiencing a surge in its stock value recently, with trading volumes exceeding 23 million shares. This notable increase comes as the company prepares for an exciting new phase in its clinical trials for liver cancer treatments.
Collaboration with Roche Holdings
Tempest has entered into a significant agreement with Roche Holdings AG (OTC: RHHBY) to propel its innovative treatment amezalpat (TPST-1120) into advanced trials. This therapy will be evaluated alongside atezolizumab (Tecentriq) and bevacizumab, the established standard for treating unresectable or metastatic hepatocellular carcinoma (HCC).
Phase 3 Trial Details
The collaboration aims to initiate a Phase 3 trial, where Tempest will lead the study while Roche supplies atezolizumab on a global scale. This agreement is a continuation of earlier clinical collaborations where amezalpat was tested in combination with the other treatments.
Clinical Benefits and Positive Data
The momentum behind this partnership is bolstered by recent positive outcomes from a Phase 2 study, where significant survival benefits were observed among patients receiving the combination therapy. “Based on the positive Phase 2 data, I believe this combination therapy holds the potential to significantly improve first-line liver cancer treatment,” remarked Stephen Brady, Tempest’s CEO.
Key Observations from the Study
The data demonstrated a remarkable six-month increase in median overall survival for participants receiving the amezalpat combination compared to those treated with only atezolizumab and bevacizumab. Notably, the positive effects were consistent across various patient subpopulations.
Looking Ahead: Phase 3 Preparation
Tempest is actively preparing to commence the Phase 3 study in the first quarter of 2025, aimed at further validating the benefits observed in earlier trials. The prospects of amezalpat as a competitive treatment option are growing stronger.
Current Market Performance
In recent market activity, TPST stock is showing impressive gains, with a reported increase of 23% bringing the price to $1.66 during premarket trading, indicating robust investor interest and confidence in the company's pipeline.
Frequently Asked Questions
What is Tempest Therapeutics' main focus?
Tempest Therapeutics is focused on developing novel treatments for cancer, particularly its amezalpat therapy.
How will the partnership with Roche impact Tempest?
The partnership allows Tempest to leverage Roche’s resources and capabilities to advance its pivotal Phase 3 clinical trial.
What are the expected benefits of the amezalpat therapy?
Amezalpat is designed to improve survival rates in liver cancer patients, showing promise in recent clinical studies.
When is the Phase 3 trial expected to begin?
The Phase 3 trial is anticipated to start in the first quarter of 2025.
What has driven the stock price increase for TPST?
The stock price increase is largely due to the positive clinical data and the strategic agreement with Roche Holdings to advance their liver cancer research.
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