Strategic Move by Serina Therapeutics Strengthens Financials

Serina Therapeutics Announces Sale of UniverXome Subsidiary

- Transaction eliminates $11.2 million in debt, strengthening financial position -

HUNTSVILLE, AL -- Serina Therapeutics Inc. (NYSE American: SER), a clinical-stage biotechnology company known for its innovative POZ Platform drug delivery technology, has revealed the successful sale of its UniverXome subsidiary. This strategic decision was made to eliminate $11.2 million in associated subsidiary-level debt, positioning the company with a solid financial foundation as it anticipates the new year.

The UniverXome subsidiary was created before Serina’s merger with AgeX Therapeutics, facilitating the hold of legacy assets from its predecessor company. This sale not only clears significant debt but also allows Serina to concentrate on its core mission.

Strengthening Financial Positions and Future Directions

Steve Ledger, the CEO of Serina, emphasized the importance of this transaction for the organization's strategic focus. Ledger stated, “This transaction underscores our commitment to maintaining a focused operational strategy centered on advancing SER-252, our lead candidate for advanced Parkinson’s disease, into clinical development. By achieving a debt-free balance sheet, we have strengthened our financial foundation, enabling us to accelerate our patient-driven mission.”

Advancing SER-252 into Clinical Development

SER-252 is an investigational apomorphine therapy that leverages Serina’s proprietary POZ platform to provide continuous dopaminergic stimulation (CDS). Research suggests that CDS effectively diminishes the severity of levodopa-related motor complications in individuals with Parkinson’s disease. Preclinical studies are promising, indicating that SER-252 could deliver these benefits without causing skin adverse reactions, hence integrating smoothly into clinical testing set for 2025.

Unveiling the POZ Technology

The POZ technology at Serina is centered around a specialized synthetic polymer known as poly(2-oxazoline). This innovative approach to drug delivery is characterized by its water solubility and low viscosity, which greatly enhances control over drug loading and improves precision in the rate of drug release via subcutaneous injection.

Broad Applications Across Therapeutic Modalities

Serina’s POZ technology is designed to address various limitations faced by therapeutics, including toxicity, side effects, and short half-life. By employing this platform, the company aims to enhance drugs that have narrow therapeutic windows, ensuring more stable blood levels of medications. The versatility of the POZ platform positions it as a foundational element for future drug candidates, targeting a range of therapeutic indications.

Serina Therapeutics' Pipeline and Vision

With a firm grounding in the neurotherapeutic space, Serina is dedicated to advancing its pipeline of wholly-owned drug product candidates, particularly aimed at tackling neurological diseases. The POZ Platform holds the promise to enhance the efficacy and safety profiles across diverse modalities, which is critical for small molecules, RNA-based therapeutics, and antibody-based drug conjugates (ADCs).

Serina is keen to expand its offerings through licensing and collaborative development agreements, highlighting an existing non-exclusive partnership with Pfizer, Inc. This collaboration allows for the application of the POZ polymer technology in lipid nanoparticle drug delivery formulations, showcasing Serina's commitment to innovation and partnership in biotechnological advancements.

Company Overview and Future Aspirations

Based in Huntsville, Alabama, Serina Therapeutics is a dynamic player in the biotechnology sector, striving to improve treatment options for neurological conditions and more. As the company progresses, it continues to build on the foundation laid by its proprietary POZ Platform, poised to make significant contributions to the healthcare landscape.

For more detailed insights into our technology and ongoing projects, please visit Serina Therapeutics.

Frequently Asked Questions

What prompted Serina Therapeutics to sell its UniverXome subsidiary?

The sale was initiated to eliminate $11.2 million in subsidiary-level debt, aiming to strengthen the company's financial position as it gears up for 2025.

How does the POZ Platform benefit drug delivery?

The POZ Platform enhances drug loading and precision in drug release, addressing key limitations in therapeutics such as toxicity and short half-life.

What is SER-252, and why is it significant?

SER-252 is an investigational therapy for Parkinson's disease designed to provide continuous dopaminergic stimulation, which may reduce related motor complications effectively.

What collaborations is Serina involved in currently?

Serina has a non-exclusive licensing agreement with Pfizer, Inc. to utilize its POZ polymer technology in lipid nanoparticle drug delivery formulations.

What is Serina's primary focus moving forward?

Serina aims to advance its pipeline of drug candidates for neurological diseases while exploring further applications for its POZ platform.

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