Spyre Therapeutics Unveils Promising Data at Major Gastro Event

Exciting Developments from Spyre Therapeutics at Recent Gastroenterology Event

Spyre Therapeutics, Inc. (NASDAQ: SYRE), a pioneering name in the biotechnology sector focused on advancing innovative treatments for Inflammatory Bowel Disease (IBD) and other immune-mediated diseases, recently showcased significant research at the United European Gastroenterology Week (UEGW) congress. The event is a global platform for scientific presentations and discussions related to digestive health.

Noteworthy Findings from the Phase 1 Study of SPY002

During the congress, Spyre Therapeutics presented compelling follow-up data from their Phase 1 study of SPY002, an anti-TL1A antibody. This potential best-in-class treatment has demonstrated notable efficacy and safety, maintaining a favorable profile over six months. Josh Friedman, M.D., Ph.D., Senior Vice President of Clinical Development, expressed enthusiasm about the results, emphasizing that the data indicate SPY002 is not only well tolerated but also supports an innovative dosing strategy with potential quarterly or biannual administration.

Combination Therapies Show Enhanced Efficacy

The company also unveiled new preclinical data which highlighted the superiority of their combination therapies. These combinations include integrin ?7 with TL1A, integrin ?7 with IL-23, and TL1A with IL-23. They displayed greater efficacy in rodent models of TNBS-induced colitis compared to traditional monotherapies. This data provides a robust foundation for Spyre's ongoing SKYLINE-UC Phase 2 study, aimed at exploring these innovative combinations further in a clinical setting.

Details of the Presentations

Spyre's presentations highlighted two key studies:

Title: Interim Phase 1 Results for SPY002, Indicating Potential for Q3M or Q6M Maintenance Dosing for IBD.
Authors: A collaboration of leading experts in the field including Y. Vugmeyster and J. Friedman.

Title: Combined Inhibition Strategies in Mouse TNBS-Induced Colitis Show Superiority to Monotherapies.
Authors: M. Siegel, J. Friedman, and others contributed to this ground-breaking analysis.

About Spyre Therapeutics

Spyre Therapeutics stands out in the biotechnology realm with its commitment to developing groundbreaking therapies for IBD and other immune-mediated conditions. By leveraging cutting-edge antibody engineering and optimizing dosing strategies, the company aspires to deliver effective treatment options that significantly enhance patient outcomes. Their pipeline promises extended half-life antibodies targeting ?4?7, TL1A, and IL-23, which could transform therapeutic approaches in the field.

Investor and Media Inquiries

For Investors:
Reach out to Eric McIntyre, Vice President of Finance and Investor Relations, via email at Eric.mcintyre@spyre.com.

For Media:
Contact Josie Butler at josie@1abmedia.com for media inquiries related to Spyre Therapeutics.

Frequently Asked Questions

What is Spyre Therapeutics known for?

Spyre Therapeutics focuses on developing treatments for Inflammatory Bowel Disease and other immune-mediated conditions through advanced antibody engineering.

What is SPY002?

SPY002 is an anti-TL1A antibody that has shown promising results for the treatment of IBD, suggesting a potential for innovative dosing strategies.

What are combination therapies?

Combination therapies involve using more than one treatment method to increase efficacy, which Spyre is investigating with their TL1A and integrin combinations.

Who should be contacted for more information about Spyre Therapeutics?

For investor relations, Eric McIntyre is the VP to contact, while media inquiries can be directed to Josie Butler.

How does Spyre ensure the effectiveness of their treatments?

Spyre conducts rigorous clinical studies and preclinical research to validate the safety and efficacy of its therapeutic candidates.

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