Sonnet BioTherapeutics to Showcase Innovations in Immunotherapy

Sonnet BioTherapeutics Advances in Immunotherapy

Sonnet BioTherapeutics Holdings, Inc. (NASDAQ: SONN) is making significant strides in the field of oncology, thanks to its innovative approach to immunotherapeutic drug development. The company recently announced an exciting opportunity to present its research at an esteemed conference dedicated to cancer research.

Exciting Presentation at the AACR IO Conference

Sonnet will showcase its research through a poster presentation at the upcoming 2025 American Association for Cancer Research (AACR) IO Conference. This integral event will be held from February 23-26, 2025, at the JW Marriott in Los Angeles. The conference is a gathering of top minds in cancer research, offering an ideal platform for Sonnet to present its findings.

Details of the Presentation

During the conference, Sonnet's poster presentation will include a detailed overview of:

Session: Poster Session B
Abstract title: Combination immunotherapy with an albumin-binding interleukin-12 fusion protein that extends cytokine half-life, targets the tumor microenvironment, and enhances therapeutic efficacy
Session Date and Time: Tuesday, February 25, 2025, from 1:45-4:45 PM PT

Understanding Sonnet's Innovative Approach

At the core of Sonnet's strategy is its proprietary F_HAB (Fully Human Albumin-Binding) technology, which empowers the development of targeted biologics. This innovative platform is designed to optimize the delivery and efficacy of drugs by utilizing a fully human single chain antibody fragment that binds to human serum albumin for more effective transport to target tissues.

The Future of Oncology Treatments

Sonnet’s lead program, SON-1010, represents a significant advancement in the treatment of advanced solid tumors, including certain sarcomas and platinum-resistant ovarian cancer. This product, an IL-12-F_HAB, is currently undergoing evaluation in a Phase 1/2a clinical trial. In collaborative efforts with Roche, SON-1010 is being tested with atezolizumab (Tecentriq), highlighting the potential for synergistic effects in treating challenging cancers.

Additional Candidates in Development

In addition to SON-1010, Sonnet is also working on another promising candidate, SON-1210. This IL12-F_HAB-IL15 is being explored for solid tumors in conjunction with the Innovative Immuno-Oncology Consortium (IIOC). Plans are underway to initiate a Phase 1/2a study targeting locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC), emphasizing the company’s commitment to addressing unmet medical needs in oncology.

Addressing Neuropathies

Moreover, the company is developing SON-080, a low-dose construct of rhIL-6 aimed at treating Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Diabetic Peripheral Neuropathy (DPN). Results from a recent Phase 1b/2a trial have shown that SON-080 is well tolerated, with no significant pro-inflammatory responses observed. This led to a license agreement with Alkem Laboratories to advance SON-080 into a Phase 2 study focused on DPN.

Conclusion: A Bright Future Ahead

With its robust pipeline and commitment to innovation, Sonnet BioTherapeutics stands at the forefront of oncological therapeutics. The upcoming presentation at the AACR IO Conference marks a vital opportunity for the company to share its groundbreaking research with the scientific community and demonstrate the potential of its advanced therapies to improve patient outcomes.

Frequently Asked Questions

What is SONN's main area of focus?

Sonnet BioTherapeutics focuses on developing targeted immunotherapeutic drugs to treat various forms of cancer.

When and where will the AACR conference take place?

The AACR IO Conference will be held from February 23-26, 2025, at the JW Marriott in Los Angeles.

What are the key products Sonnet is developing?

Sonnet is developing several key products, with notable mentions including SON-1010 and SON-080, targeting advanced solid tumors and neuropathies.

Can you explain the F_HAB technology?

F_HAB technology is designed to optimize drug delivery using a human antibody fragment that binds to serum albumin, enhancing therapeutic efficacy.

Who can be contacted for investor relations?

Investor relations inquiries can be directed to Jenene Thomas at JTC Team, LLC, by calling 908-824-0775 or emailing SONN@jtcir.com.

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