Silexion's Strategic Alliance with Catalent: A Game Changer

Silexion Therapeutics Forms Key Partnership with Catalent

Silexion Therapeutics Corp. (NASDAQ: SLXN) has recently announced a groundbreaking collaboration with Catalent, a prominent global leader in advanced delivery systems and therapeutics manufacturing. This partnership is poised to elevate the development of Silexion's next-generation siRNA therapeutic, SIL204, targeting KRAS-driven cancers, a particularly aggressive form of cancer affecting many patients worldwide.

Details of the Collaboration

As part of this strategic agreement, Catalent will take charge of formulation development and clinical manufacturing activities for SIL204 at its cutting-edge facility in Limoges, France. This collaboration is designed to optimize the systemic and intratumoral delivery methods of SIL204, in line with Silexion’s innovative dual-route development strategy aimed at effectively combating both primary tumors and metastases in KRAS-driven cases.

The Scientific Significance of SIL204

SIL204 has shown promise in recent preclinical studies, demonstrating its potential to significantly reduce tumor growth and prevent metastasis in models of clinically relevant pancreatic cancer. What sets SIL204 apart is its ability to target a wide array of KRAS mutations, including G12D, G12V, G12R, Q61H, and G13D, which are known to be pivotal in the progression of various cancers including pancreatic, colorectal, and lung cancers.

Expert Opinions on the Collaboration

Ilan Hadar, the Chairman and CEO of Silexion Therapeutics, expressed his enthusiasm about the partnership with Catalent, noting, "Our collaboration with Catalent marks a significant milestone in advancing our SIL204 program. With their expertise in sophisticated formulation development, we aim to expedite our preparations for human clinical trials, which we anticipate launching in the first half of the following year." Catalent's Limoges facility is recognized as a European center for excellence in clinical biologics formulation development and manufacturing.

Innovating Delivery Technologies

This alliance will capitalize on Catalent's extensive experience in creating stable, sustained-release technologies, crucial for enhancing SIL204’s therapeutic efficacy. By improving the stability and bioavailability of SIL204, this partnership aims to bring forth innovative solutions that could make a real difference in the treatment of KRAS-driven cancers.

Future Plans for SIL204

Silexion's commitment to accelerating SIL204's progress is evident. The company plans to execute further toxicology and pharmacodynamic studies throughout the year, leading to potential regulatory submissions to health authorities in both the Israel Ministry of Health and the European Union in the upcoming periods. This comprehensive approach illustrates Silexion's unwavering dedication to spearheading advancements in oncology.

About Silexion Therapeutics

Silexion Therapeutics is at the forefront of developing innovative RNA interference (RNAi) treatments aimed at addressing solid tumors driven by KRAS mutations, known for being the most prevalent oncogenic drivers in cancers. Their initial product, LODER™, demonstrated promising outcomes in Phase 2 trials for non-resectable pancreatic cancer, laying a strong foundation for their pipeline. The company is steadfast in its mission to enhance therapeutic options for patients grappling with challenging cancers through groundbreaking innovations.

Frequently Asked Questions

What is SIL204?

SIL204 is a next-generation siRNA therapeutic developed by Silexion Therapeutics targeting KRAS-driven cancers.

What is the significance of Silexion's partnership with Catalent?

This collaboration focuses on formulating and manufacturing SIL204, enhancing its delivery mechanisms for better therapeutic outcomes.

When are human clinical trials expected to begin?

Silexion anticipates initiating human clinical trials for SIL204 in the first half of the coming year.

What types of cancers does SIL204 target?

SIL204 targets a range of KRAS mutations involved in pancreatic, colorectal, and lung cancers.

How does Catalent contribute to this collaboration?

Catalent brings its expertise in complex formulation development and clinical biologics to enhance the stability and effectiveness of SIL204.

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