Silexion Therapeutics Advances SIL-204 for KRAS Cancer Treatment
Breakthrough in Cancer Treatment with SIL-204
Silexion Therapeutics Corp. (NASDAQ: SLXN), a pioneering biotech company in RNA interference (RNAi) therapies, has achieved significant milestones in its preclinical studies for SIL-204, a state-of-the-art siRNA candidate developed to fight KRAS-driven cancers. This innovative compound has demonstrated a remarkable ability to reduce tumors in mouse models, particularly those exhibiting the KRAS G12D mutation, a common and aggressive type of pancreatic cancer.
Effective Microparticle Formulation
The latest findings underscore the effectiveness of the new microparticle formulation of SIL-204, which has shown a marked improvement in tumor reduction compared to earlier versions. This advanced encapsulation technique leads to a substantial anti-tumor response and a notable increase in tumor necrosis, thus indicating a promising therapeutic potential. The new PLGA microparticles provide an extended-release profile that significantly enhances the drug's performance.
Future Trials and Expansion of Research
Silexion has outlined plans to move forward with toxicology studies for SIL-204 soon, paving the way for Phase 2/3 clinical trials projected to begin in early 2026. The immediate objective is to target locally advanced pancreatic cancer, a condition known for its high mortality rates. Moreover, the company is set to expand its research to include preclinical trials focused on colorectal cancer, further widening its therapeutic scope.
CEO’s Confidence in SIL-204
Ilan Hadar, the Chairman and CEO of Silexion, expressed a positive outlook on SIL-204, emphasizing the drug's optimized cellular uptake and the improved formulation as key components of its progress. With SIL-204, Silexion aims to address a broader spectrum of KRAS mutations, bolstering its commitment to developing effective treatments for challenging cancers.
Progress of First-Generation Product LODER
In tandem with this, Silexion's first-generation product, LODER, has shown promising results in a Phase 2 trial targeting non-resectable pancreatic cancer. The trial reported a 56% objective response rate among participants, along with a 67% increase in the resectability of previously inoperable tumors. Such results suggest that LODER, especially when combined with standard chemotherapy, could significantly enhance surgical options for patients.
Next-Generation Developments and Corporate Changes
Continuing to innovate, Silexion is developing the next-generation product SIL-204, which is designed to target a wider range of KRAS mutations associated with various cancers. Preclinical studies indicate that SIL-204 displays enhanced stability and effectiveness in reaching and silencing the KRAS oncogene, showing significant promise for the future.
In recent corporate news, Silexion announced the resignation of board member Ilan Shiloah, who stepped down due to competing commitments. This change opens up vacancies on several important committees, including audit, compensation, and corporate governance. Additionally, the company has undergone a recent merger with Moringa Acquisition Corp, transitioning from its former name, Biomotion Sciences, to Silexion Therapeutics Corp. These updates reflect the company's dynamic evolution in the biotech landscape.
Frequently Asked Questions
What is SIL-204?
SIL-204 is a second-generation siRNA candidate developed by Silexion Therapeutics Corp. aimed at treating KRAS-driven cancers, including pancreatic cancer.
What are the advancements in SIL-204's formulation?
The new microparticle formulation of SIL-204 has shown substantial tumor reduction in preclinical models, indicating improved anti-tumor activity and an extended-release profile.
When is Silexion planning to begin clinical trials for SIL-204?
Silexion expects to initiate Phase 2/3 clinical trials for SIL-204 in the first half of 2026, initially focusing on locally advanced pancreatic cancer.
What has been the performance of Silexion's first-generation product LODER?
LODER has shown positive results in its Phase 2 trial for non-resectable pancreatic cancer, with a 56% objective response rate and increased resectability of tumors.
What corporate changes has Silexion undergone recently?
Recently, Silexion underwent a merger with Moringa Acquisition Corp and changed its name from Biomotion Sciences to Silexion Therapeutics Corp, reflecting its growth in the biotech industry.
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