Significant Enrollment Milestone Achieved for Namodenoson Study
Exciting Progress in Can-Fite's Namodenoson Study
Can-Fite BioPharma Ltd. (NYSE American: CANF) is making notable strides in its clinical trial for Namodenoson, a promising treatment for pancreatic cancer. The company recently announced that it has reached an important milestone, achieving over 50% enrollment in its Phase 2a trial.
Understanding the Trial and Its Significance
This Phase 2a trial represents a multicenter, open-label study focused on patients with advanced pancreatic adenocarcinoma. These patients have experienced disease progression after at least one previous treatment. The core aim of this study is to evaluate the safety of Namodenoson, along with assessing its clinical activity and pharmacokinetics.
Each participant receives Namodenoson in an oral form, with a dosage of 25 mg administered twice daily within cycles lasting 28 days. The dedicated monitoring for safety has shown that Namodenoson maintains a favorable safety profile, a promising aspect for its further development.
Leadership in Oncology Research
The leadership of this study comes from Prof. Salomon Stemmer, a respected oncologist at the Davidoff Center in Rabin Medical Center. He emphasizes the growing interest in Namodenoson, noting it as a strong candidate for the treatment of one of the most challenging cancers.
Patient-Centric Approach and Commitment
Pnina Fishman, Ph.D., the Chief Scientific Officer of Can-Fite, expressed enthusiasm regarding the trial's pacing and the continued dedication to advancing Namodenoson as a crucial therapeutic option. This reflects a patient-centric approach where the needs of individuals battling pancreatic cancer are at the forefront of the company’s mission.
Innovative Mechanism of Action
Namodenoson operates as a selective A3 adenosine receptor (A3AR) agonist. What makes it particularly interesting is its demonstrated anti-tumor activity in preclinical studies focused on pancreatic cancer. Moreover, this medication is also under investigation for treating advanced liver cancer, expanding its potential area of impact.
Regulatory Milestones for Namodenoson
This remarkable treatment has already received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA), highlighting its significance in addressing unmet medical needs for pancreatic cancer patients. Such regulatory milestones not only support the drug's credibility but also pave the way for future clinical applications.
About Can-Fite BioPharma Ltd.
Can-Fite BioPharma is a clinical-stage biotechnology firm focused on developing innovative therapies for cancer and inflammatory diseases. Aside from Namodenoson, the company is working on several candidates, including Piclidenoson, which recently reported positive results in a Phase 3 trial targeting psoriasis.
Expansive Clinical Development Initiatives
The company’s strategic portfolio includes Namodenoson being investigated in multiple trials: a Phase III for hepatocellular carcinoma (HCC), a Phase 2b trial for MASH, and the current Phase 2a study on pancreatic cancer. These initiatives highlight Can-Fite’s robust commitment to addressing critical medical challenges.
Can-Fite's other drug candidate, CF602, has shown efficacy in treating erectile dysfunction, showcasing a diverse therapeutic pipeline. Each of these candidates has an excellent safety profile, supported by data from over 1,600 patients involved in clinical studies.
Frequently Asked Questions
What is the primary goal of the Namodenoson trial?
The primary goal of the Namodenoson trial is to evaluate its safety profile, along with its clinical activity and pharmacokinetics in patients with pancreatic cancer.
Who is leading the trial for Namodenoson?
The trial is led by Prof. Salomon Stemmer, a notable oncologist at the Davidoff Center, Rabin Medical Center.
What significance does the 50% enrollment milestone hold?
The 50% enrollment milestone reflects strong interest and engagement from both investigators and patients in Namodenoson as a treatment option.
Has Namodenoson received any regulatory designations?
Yes, Namodenoson has received Orphan Drug Designation from the U.S. FDA, highlighting its potential in treating pancreatic cancer.
What other therapeutic areas is Can-Fite exploring?
Aside from pancreatic cancer, Can-Fite is also investigating Namodenoson for advanced liver cancer and other cancers including colon, prostate, and melanoma.
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