Revolutionary Biomarker Insights on CTX-471 at SITC Meeting

Groundbreaking Biomarker Data on CTX-471

Compass Therapeutics, Inc., renowned for its commitment to advancing oncology treatments, has recently unveiled novel insights into CTX-471, a pioneering anti-CD137 agonist antibody. At a prestigious oncology conference, the company presented significant new data demonstrating the link between neural cell adhesion molecule (NCAM or CD56) levels and patient responses, along with disease control achieved through CTX-471 monotherapy.

Insights from Latest Clinical Findings

During the Phase 1 study of CTX-471, researchers observed notable correlations between predictive biomarkers and patient responses, showcasing the potential for NCAM to serve as both a measure and a target in cancer treatment. This findings from this clinical trial emphasize the importance of ongoing research into CTX-471’s biologically active mechanisms.

Clinical Activity and Future Directions

Compass’s presentation titled “Pharmacodynamic and Response Biomarkers in the Monotherapy Arm of a Phase 1 Trial of CTX-471” highlighted data gathered from a cohort of patients whose cancers had progressed while on approved PD-1 or PD-L1 inhibitors. These patients were evaluated in a tilting landscape for modern oncological therapies, where each data point contributes to understanding CTX-471's role in enhancing patient response.

Significance of the Findings

Thomas Schuetz, MD, PhD, CEO of Compass, emphasized the groundbreaking nature of this new data, which points to a previously unknown connection between NCAM levels and therapeutic outcomes. This correlation suggests that identifying NCAM in tumor cells could expand the drug’s applicability to a larger patient population. The team is now strategizing to launch a Phase 2 basket study focusing on patients with NCAM-expressing tumors.

Data Highlights from the Presentation

The poster presented during the meeting shed light on several significant findings:

• Pharmacodynamic changes with CTX-471 were in alignment with signs of immune system activation.
• Measurable biomarkers at baseline were associated with effective disease control outcomes.
• Expression of NCAM/CD56 in tumor cells contributed notably to responses and control over disease progression.
• Identification of a novel circulating cell phenotype linked to promising responses to CTX-471 therapy.

Understanding CTX-471

CTX-471 is not just an ordinary antibody; it represents a fully human monoclonal antibody that targets and activates CD137, a celebrated marker in immuno-oncology. Preliminary studies have showcased its robust ability to induce an immune response, made evident through longitudinal studies that track patient responses over time. Currently, CTX-471 is being scrutinized in a Phase 1b trial aimed at solid tumors that show resistance following standard checkpoint inhibitors.

Performance in Clinical Trials

Results so far have been promising, including a notable durable partial response in patients battling conditions like small-cell lung cancer. Compass continues to gather and analyze data to strengthen its competitive stance in the oncological treatment field.

Overview of NCAM (CD56)

Neural cell adhesion molecule (NCAM) is pivotal in various cellular functions, particularly in cancer biology, where it is linked to tumor aggression and metastases. The prevalence of NCAM expression in tumors reflects a significant avenue for targeted therapies, potentially including CTX-471.

About Compass Therapeutics

Founded in 2014 and based in Boston, Massachusetts, Compass Therapeutics focuses on transforming the landscape of cancer treatment through innovative therapies like CTX-471. The company is dedicated to the interplay of angiogenesis and the immune system, driving the development of antibodies that can improve patient outcomes significantly. Their commitment includes trials and product innovations that examine the complexities of the tumor landscape.

Contact Information

For inquiries or more detailed information about the ongoing research, interested parties can contact:

Investor Relations: ir@compasstherapeutics.com

Media Contact: Anna Gifford
Senior Manager of Communications
Phone: 617-500-8099

Frequently Asked Questions

What is CTX-471?

CTX-471 is an innovative anti-CD137 agonist monoclonal antibody being developed for cancer treatment.

What has recent data shown about CTX-471?

Recent studies have highlighted a correlation between NCAM levels and patient responses to CTX-471, indicating potential for broader applications.

What are the next steps for Compass Therapeutics?

Compass plans to initiate a Phase 2 basket study for CTX-471 in patients with NCAM-expressing tumors.

How does NCAM influence cancer treatment?

NCAM is linked to tumor metastasis and aggressiveness, making it a crucial biomarker for targeted therapies like CTX-471.

What is Compass Therapeutics' mission?

Compass aims to innovate cancer treatment through proprietary antibody-based therapies that address critical biological pathways.

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