Recursion's REC-1245 Receives FDA Clearance for Clinical Trials
FDA Grants Clearance for REC-1245 Clinical Trials
Recursion, a prominent TechBio company known for its advanced biological insights, has reached a significant milestone recently with the FDA granting clearance for its investigational new drug application related to REC-1245. This new drug is a potential first-in-class RBM39 degrader aimed at treating biomarker-enriched solid tumors and lymphoma. This advancement showcases Recursion's innovative approach to drug development, leveraging cutting-edge technology to streamline the discovery process.
Accelerated Drug Discovery through AI Innovation
One of the most remarkable aspects of REC-1245's development is its astonishing timeline. With the integration of AI-enabled active learning modules, Recursion successfully accelerated the process of target identification and subsequent studies necessary for the IND application. This approach has allowed the company to transition from discovery to drug candidate in less than 18 months, a feat that is significantly faster than the industry standard.
Targeting RBM39 for Biomarker-Enriched Patients
Dr. Chris Gibson, Recursion’s Co-founder and CEO, expressed the company’s enthusiasm about REC-1245, highlighting its innovative mechanism of action. By targeting the RBM39 protein, REC-1245 may offer a therapeutic option for patients who have limited prospects with conventional treatments. This targeted approach aims to optimize patient outcomes in solid tumor patients and those with lymphoma, anticipating a treatment option that is both robust and effective.
Clinical Trials Set to Begin
The planning for the upcoming Phase 1/2 clinical trial is already underway, with dosing anticipated to commence in the fourth quarter. This trial aims to assess the drug's safety, tolerability, and efficacy in a biomarker-enriched population. Such a focused approach not only ensures participant safety but also maximizes the potential of REC-1245 to demonstrate clinical benefit where traditional therapies might fall short.
Implications of RBM39 Degradation
The degradation of RBM39 represents an exciting and promising pathway for treating solid tumors. Preclinical studies indicate that targeting this pathway could disrupt critical cellular processes, particularly concerning DNA damage response networks. As Najat Khan, Recursion’s Chief R&D Officer, notes, the potential therapeutic implications of this degradation could reshape treatment strategies for many patients facing aggressive cancers.
About Recursion: Innovating Drug Discovery
Founded on the principles of advanced technology application in drug discovery, Recursion (NASDAQ: RXRX) combines vast datasets and machine-learning algorithms to uncover novel biological and chemical relationships. This robust platform enables extensive research and experimentation, propelling the drug discovery process at an unprecedented scale.
Headquartered in Salt Lake City, Recursion has established itself as a key player in the biotech sector, leveraging state-of-the-art computational resources and experimental methodologies. With a relentless focus on improving patient outcomes, the company is set to continue making strides in the discovery and development of transformative therapeutics.
Frequently Asked Questions
What is REC-1245?
REC-1245 is a potential first-in-class RBM39 degrader developed by Recursion for treating biomarker-enriched solid tumors and lymphoma.
When will the clinical trial for REC-1245 start?
The Phase 1/2 clinical trial is expected to initiate in the fourth quarter.
How fast was REC-1245 developed?
Recursion successfully progressed REC-1245 from target identification to drug candidate status in under 18 months, which is significantly faster than the industry average.
What are the therapeutic implications of RBM39 degradation?
RBM39 degradation may offer new treatment opportunities for patients with solid tumors, particularly those who are often unresponsive to traditional therapies.
Where is Recursion located?
Recursion is headquartered in Salt Lake City and also has offices in Toronto, Montréal, London, and the San Francisco Bay Area.
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