Purple Biotech Unveils Impressively Innovative CAPTN-3 Platform

Revolutionary Advancements in Biotech

Purple Biotech Ltd. (NASDAQ/TASE: PPBT), a forward-thinking clinical-stage company based in Rehovot, Israel, is on a mission to develop cutting-edge therapies that tackle tumor immune evasion and drug resistance. Recently, Purple Biotech showcased groundbreaking data regarding its novel CAPTN-3 tri-specific antibody platform at the European Association for Cancer Research (EACR) Annual Congress.

A Game-Changing Presentation at EACR 2025

During the EACR 2025 congress, Purple Biotech's team presented exciting new preclinical data demonstrating the advantages of the CAPTN-3 platform. This impressive data reveals how the platform excels at creating multiple antibodies that respond to various targets. CEO Gil Efron emphasized that the unique design of CAPTN-3 allows safe activation of both the innate and adaptive immune systems, emphasizing the platform's flexibility and efficiency.

Understanding CAPTN-3

The CAPTN-3 platform is designed with tri-specific antibodies that feature innovative arms for binding. One arm selectively engages CD3 after activation in the tumor microenvironment (TME), while another engages NK cells. This practical approach means that the CAPTN-3 can act directly where it is needed most, facilitating a coordinated attack on the tumor without triggering unwanted side effects.

Unique Features of the Platform

This platform also incorporates an anti-NKG2A arm, a vital component that plays a significant role in the immune checkpoint process. In cancer, this mechanism often leads to T cell exhaustion within the TME, making it challenging for the immune system to fight effectively. However, CAPTN-3’s ability to reinvigorate these exhausted T cells stands out as a significant advancement in immunotherapy.

Key Advantages Highlighted

The presentation included several key highlights from the results achieved with the CAPTN-3 platform:

• Robust In Vivo Anti-Tumor Activity: The lead tribody, IM1240, has shown exceptional potential in sustaining tumor regression, particularly demonstrated in models of triple-negative breast cancer.
• Conditional Activation Specificity: The capped-CD3 arm remains inactive in blood samples from patients, only activating upon exposure to TME proteases. This innovative mechanism enhances safety by protecting healthy cells from depletion.
• Enhanced Dual Engagement: By activating both T cells and NK cells, IM1240 boosts overall immune responses against tumors, showcasing increased cytotoxic efficacy during trials.
• Modular Flexibility: With the capacity to develop various CAPTN-3 tribodies, such as IM1060 and IM1065, this platform reveals promising modularity and customization, further enhancing its therapeutic applications.
• Improved Efficacy: The platform is outperforming traditional combinations of individual antibodies, marking a significant shift in how cancer therapies may be structured moving forward.

Next Steps for Purple Biotech

As the company continues to refine the CAPTN-3 platform, it is crucial to highlight how this innovative approach is set to change the landscape of cancer therapies. With a focus on local tumor environments and the promise of improved safety profiles, Purple Biotech is paving the way for more effective cancer treatments tailored to patient needs.

About Purple Biotech

Purple Biotech Ltd. remains dedicated to pioneering therapies that confront significant challenges in oncology. With an impressive lineup of candidates, including CM24, NT219, and the CAPTN-3 platform, the Company is committed to bringing new hope to patients facing difficult cancer battles. For more details about the company's ongoing projects and research, you can visit their official website.

Frequently Asked Questions

What is the CAPTN-3 tri-specific antibody platform?

The CAPTN-3 platform is a novel technology developed by Purple Biotech that combines three antibody arms targeting tumors, enhancing immune response effectively.

What are the main advantages of the CAPTN-3 platform?

The main advantages include conditional activation in the tumor microenvironment, dual engagement of T cells and NK cells, and enhanced safety through targeted actions.

How does Purple Biotech prepare for clinical trials?

Purple Biotech conducts extensive preclinical studies to demonstrate efficacy and safety before initiating clinical trials for its compounds.

What therapeutic areas does Purple Biotech focus on?

Purple Biotech primarily focuses on oncology, aiming to develop therapies that address tumor immune evasion and resistance to treatment.

What is the company's future outlook?

With innovative platforms and a strong pipeline, Purple Biotech aims to lead in developing more effective cancer therapies to underpin future successes in oncology.

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