Purple Biotech Celebrates European Patent Approval for NT219

Exciting Developments at Purple Biotech

A Phase 2 study for NT219 in combination with immunotherapy is being conducted in collaboration with the University of Colorado.

Purple Biotech Ltd. (NASDAQ/TASE: PPBT), a pioneering clinical-stage company in the realm of oncology, has made some thrilling announcements regarding its innovative therapies. Recently, the European Patent Office has expressed an intention to grant a European Patent for its Application No. 20168234.1, which focuses on the theme 'Combinations of IRS/STAT3 Dual Modulators and Anti-Cancer Agents for Treating Cancer.'

Details on the Patent Application

This patent grant is a significant milestone for Purple Biotech as it aims to assert broad protections for NT219 combinations, especially with renowned immunotherapies like anti-PD-1, PD-L1, CTLA-4, and CD20 antibodies. These innovative combinations target treatment-resistant cancers, enhancing their responsiveness. Furthermore, the patent also includes combinations with MEK inhibitors, which are expected to improve treatment sensitivity for resilient tumors. The patent expresses a term running until 2036, marking a critical period for the company's advancements.

Insights from Leadership

Gil Efron, the CEO of Purple Biotech, shared insights on the potency of NT219: "NT219 binds to Insulin Receptor Substrate (IRS1/2), leading to their degradation while inhibiting STAT3. Both targets are pivotal in overcoming drug resistance and tumor immune evasion. Our combination strategy with leading immunotherapies could represent a game-changer in the fight against cancer's resistance mechanisms. We have launched a Phase 2 study to evaluate NT219 either alongside pembrolizumab or cetuximab for those battling squamous cell carcinoma of the head and neck (SCCHN)."

Preclinical Support and Phase 2 Study

The strong preclinical studies have paved the way for this Phase 2 clinical trial, illustrating the synergistic relationship of NT219 with immunotherapy in managing refractory tumors across various indications. Results have displayed the potential to transform the tumor microenvironment from immunosuppressive to immunoreactive, a concept that was reported at significant upcoming conferences like AACR 2023 and AACR 2025.

Understanding Purple Biotech’s Vision

Purple Biotech is devoted to developing groundbreaking therapies designed to counteract tumor immune evasion and drug resistance. Key components of their pipeline include CAPTN-3, CM24, and NT219. CAPTN-3, for example, introduces a new approach with its conditionally activated tri-specific antibodies aimed at bolstering localized immune responses within the tumor microenvironment. This targeted strategy is expected to enhance the therapeutic window for patients.

Innovative Therapies in Development

CM24, another significant aspect of Purple Biotech’s offerings, is a humanized monoclonal antibody that effectively blocks CEACAM1. This target is crucial as it supports tumor immune evasion, impacting cancer survival through multiple pathways. The company's recent Phase 2 study combining CM24 with the anti-PD-1 checkpoint inhibitor nivolumab, alongside chemotherapy, revealed substantial improvements across efficacy endpoints and identified biomarkers that might further guide treatment personalization.

The Path Ahead for Purple Biotech

Purple Biotech's NT219 stands out as a novel small molecule that effectively inhibits IRS1/2 and STAT3 simultaneously. The compelling results from earlier Phase 1 studies confirm its anti-tumor activity, particularly when paired with cetuximab for patients battling recurrent and/or metastatic SCCHN. With its collaboration with the University of Colorado, advancement towards treating R/M SCCHN indicates a robust commitment to innovative cancer therapies.

Conclusion

The company is adamant about combating the challenges that come with cancer treatment and continuously seeks new ways to enhance patient outcomes. As they push through the complexities of drug development and clinical trials, the ongoing advancements spotlight their dedication to revolutionizing cancer therapy.

Frequently Asked Questions

What is Purple Biotech's focus area?

Purple Biotech focuses on developing therapies aimed at overcoming tumor immune evasion and drug resistance within cancer treatment.

What recent patent has Purple Biotech announced?

The company has announced an intention to grant a European Patent for NT219 combinations with immunotherapies and MEK inhibitors.

What are the main therapies in Purple Biotech's pipeline?

Key therapies include CAPTN-3, CM24, and NT219, targeting various mechanisms to enhance cancer treatment efficacy.

What makes NT219 unique?

NT219 is a dual inhibitor targeting IRS1/2 and STAT3 simultaneously, which helps in combating drug resistance and immune evasion in tumors.

How is Purple Biotech advancing its research and development?

The company is conducting collaborative studies, including a Phase 2 study with the University of Colorado, to evaluate NT219 alongside established immunotherapies.

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