Pulmonx Showcases Key Clinical Findings at ERS Congress 2024
Highlights from the ERS Congress 2024
At the recent European Respiratory Society (ERS) Congress, Pulmonx Corporation, a pioneer in minimalistic treatments for severe lung diseases, unveiled crucial clinical data from the AeriSeal® CONVERT trial and the long-term outcome of the LIBERATE study. These presentations affirm the company’s commitment to enhancing the quality of life for patients currently suffering from conditions like chronic obstructive pulmonary disease (COPD) and emphysema.
AeriSeal CONVERT Trial: A New Hope
One of the focal points of the presentations was the AeriSeal CONVERT trial, which investigated the efficacy of the AeriSeal System, designed specifically to treat patients experiencing collateral ventilation. Professor Kaid Darwiche shared insights on how the trial also allowed patients previously deemed ineligible for treatment to benefit, proving the system’s versatility.
Key Findings from the CONVERT Trial
The data showcased that an impressive 77.6% of patients who were identified with collateral ventilation underwent a transformation to a collateral ventilatory negative state after treatment with the AeriSeal System. The improvements achieved post-treatment were statistically significant:
- Average lung function increased by 80 mL or 10.2% measured through Forced Expiratory Volume in 1 second (FEV1).
- Quality of life improved by 6.3 points based on St. George’s Respiratory Questionnaire metrics.
- Over a one-liter reduction in treated lobe volume was observed at the 45-day mark.
- 89% of the patients who converted reached a minimal clinically important difference of at least 350 mL in lobe volume reduction six months post-valve treatment.
These encouraging results place the AeriSeal System as a transformative option for patients with collateral ventilation, enabling them to benefit from bronchoscopic lung volume reduction facilitated by Zephyr Valves.
Durability Demonstrated in LIBERATE Study
The second segment of the presentation focused on long-term outcomes from the LIBERATE study, where Professor Gerard Criner emphasized the sustained benefits of Zephyr Valves. The data illustrated that patients who underwent valve treatment experienced durable improvements in lung function over a period extending to at least five years:
Five-Year Outcomes
- Annual lung function improvements ranged from 109 mL in the first year to 79 mL by year five, showcasing an adequate safety profile.
- Compared to traditional medical treatments where lung function typically declines, the FEV1 readings affirmed a significant advantage.
- There was no rise in respiratory adverse events from years two to five, signalizing prolonged effectiveness and tolerance for patients.
- The mortality rate among participants was 38% over five years, notably lower than the 49% seen in historically managed control subjects.
These findings from the LIBERATE study suggest the Zephyr Valves continue to provide meaningful long-term benefits to those battling severe emphysema.
Future Perspectives
Steve Williamson, President and CEO of Pulmonx, expressed his enthusiasm about the findings, highlighting a commitment to innovate treatments that can enhance patient outcomes. He indicated ongoing efforts to move forward with the next phase of clinical trials, specifically the CONVERT II pivotal trial, which aims to enroll around 200 patients and validate the AeriSeal System's effectiveness in conjunction with Zephyr Valves.
AeriSeal’s Breakthrough Status
Notably, the AeriSeal System holds a Breakthrough Device designation from the FDA and is designed to optimize lung function by disrupting collateral ventilation, advancing the potential for effective treatments in severe COPD cases. The ongoing studies and updates at ERS Congress highlight the promising trajectory of Pulmonx in revolutionizing care for patients with complex respiratory conditions.
About Pulmonx Corporation
Founded with a vision to innovate in the domain of lung care, Pulmonx Corporation (NASDAQ: LUNG) stands out globally for its efforts in minimally invasive treatment options for COPD and severe emphysema. The company believes in providing solutions that not only improve lung function but also significantly uplift the patients' quality of life. Their leading products are the Zephyr Endobronchial Valves, Chartis Pulmonary Assessment System, and the StratX Lung Analysis Platform.
Frequently Asked Questions
What were the key highlights presented at the ERS Congress 2024?
Pulmonx showcased the efficacy of the AeriSeal System and long-term benefits of Zephyr Valves in treating severe lung diseases.
What was the success rate of the AeriSeal System in the CONVERT trial?
The AeriSeal System demonstrated a 77.6% conversion rate in patients previously treated as collateral ventilation positive.
How long did the benefits of Zephyr Valves last, according to the LIBERATE study?
Patients showed durable lung function improvements extending to at least five years.
What is the purpose of the upcoming CONVERT II trial?
The CONVERT II trial aims to further assess the safety and effectiveness of the AeriSeal System with the expectation to enroll about 200 patients.
Who leads Pulmonx Corporation?
Steve Williamson serves as the President and CEO, guiding Pulmonx in its mission to enhance treatment options for severe lung diseases.
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