Promising Data on Fostrox and Lenvima in Liver Cancer
Promising Results from Medivir's Clinical Trial
Medivir AB has recently shared encouraging data from its ongoing phase 1b/2a open-label trial of fostroxacitabine bralpamide (fostrox) combined with Lenvima in patients with advanced liver cancer. This combination therapy has demonstrated improved outcomes for those receiving second-line treatment. The study reported a median time to progression (TTP) of 10.9 months, which significantly surpasses the typical TTP of 3 to 4 months seen with standard care options.
Key Findings from the Study
Response Rates and Durability
The trial results indicate that 24% of patients experienced an objective response rate (ORR), while the median duration of response lasted for 7.0 months. Notably, 19% of participants continued to receive treatment for more than a year, with the longest participant remaining on treatment for over two years. This sustained response highlights the treatment's potential efficacy across various patient backgrounds.
Safety and Tolerability Profile
In addition to its promising response rates, the safety profile of the combination therapy appears encouraging. Only one patient discontinued fostrox due to adverse events, indicating strong tolerability. Common hematological adverse events were present but temporary, allowing for long-term treatment continuation without serious complications. Importantly, no cases of febrile neutropenia or significant platelet deficiencies were reported in association with fostrox.
Mechanism of Action of Fostrox
Fostrox, as Medivir's flagship product, is a unique oral therapy designed to target liver cancer at the cellular level. Its innovative mechanism enables it to deliver a potent chemotherapy agent directly to tumor cells in the liver, minimizing damage to surrounding healthy tissue. This localized approach could represent a breakthrough in the delivery of oncology treatments.
Anticipating Future Trials
With the mature data presented at the ESMO Congress, Medivir is prepared to advance to the next stages of clinical evaluation. Preparations are underway for a phase 2b study aimed at comparing the efficacy of the fostrox and Lenvima combination against Lenvima alone. This randomized trial is poised to provide further insights into the benefits of this promising treatment approach for patients with liver cancer.
About Liver Cancer and Medivir
Hepatocellular carcinoma (HCC) remains the predominant type of liver cancer, responsible for over 80% of liver cancer cases worldwide, leading to approximately 660,000 diagnoses annually. The disease is particularly aggressive, with incidents where survival rates show less than 20% over five years. Medivir AB is dedicated to developing innovative cancer treatments targeting unmet medical needs, with a core focus on liver-related malignancies like HCC. The company's stock is listed on Nasdaq Stockholm (ticker: MVIR).
Frequently Asked Questions
What is fostrox and how does it work?
Fostrox is an orally administered liver-targeted inhibitor that selectively delivers chemotherapy to liver tumor cells, aiming to minimize damage to healthy cells.
What were the key results from the recent trial?
The trial reported a median TTP of 10.9 months and an ORR of 24%, highlighting the effectiveness of the fostrox plus Lenvima combination.
How does the safety profile of fostrox compare to other treatments?
The safety profile looked positive, with minimal discontinuation due to adverse effects and no severe complications like febrile neutropenia.
What are the next steps for Medivir?
Medivir plans to initiate a phase 2b trial to compare the effectiveness of fostrox combined with Lenvima against Lenvima alone.
Why is this research significant?
This research is crucial as it provides hope for patients with advanced liver cancer, particularly those for whom current treatments have been ineffective.
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