I won't speak for Seel but I'll toss in my 2 cents

I won't speak for Seel but I'll toss in my 2 cents. I don't think anyone is really expecting efficacy results from these early cohorts. It would be a bonus but the commenter is correct in that the does is extremely small. I posted a similar comment here back in November. It's easy to get amped up but but is pretty early for efficacy at this point IMO. The commenter goes to far in questioning efficacy in its entirety but I agree that these early cohort doses are in the basement and it's a stretch to think we'll see and efficacy results so soon. I continue to hope that we see no ill effect and expect that if we see p53 activation it will be later in the study. The problem is, we've hyped these early tests. So, if there isn't activation i think there is going to be unjustified disappointment and a little pull back in SP unless Leo releases some good news at the same time. My fingers are obviously crossed and I hope for activation but i doubt it at this point and think we're in for another non-event PR this evening. Maybe more talk about the other studies spinning up and some general housekeeping. That being said, I added to my position yesterday at 1.63 just in case. :-)