According to the article you have to inject that particular drug... You really wanna fill a syringe at home? Get out your chemistry set. And it was a preclinical study as a retinal treatment. Eye-poke? I would pass on that one...
Many common polyphenols affect the CCR5/CCL5 axis, including quercetin, curcumin, and resveratrol, along with other phytochemicals like omega-3s. Typically they don't actually occupy the receptor, but if I have it right, downregulate gene expression via NF-kb, mRNA expression, and reduce CCL5 secretion. Quercetin does seem to occupy parts of the receptor, but there are issues of binding affinity and bioavailability. And efficacy.
Back in the day, after the discovery of the receptor as the entry for the HIV virus, there was a concerted effort to find natural substances that would block the receptor as a treatment for AIDS. These were usually identified from there use in traditional Chinese or Ayurvedic medicine, but also from various ethnic medical traditions. Chinese skullcap and licorice root also came up in a recent search. Nothing was as effective as maraviroc or leronlimab, though they had some promise. Once again, bioavailability and effective dosage. Most of the studies tying these compounds to CCR5 inhibition are preclinical, so they are not a particularly good guide to human use.
I've got to get to work, but will write more later. Something a little more substantial. In the meantime, here's a couple references.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12296246/#abstract1
https://pmc.ncbi.nlm.nih.gov/articles/PMC9913...s-15-00819
Many common polyphenols affect the CCR5/CCL5 axis, including quercetin, curcumin, and resveratrol, along with other phytochemicals like omega-3s. Typically they don't actually occupy the receptor, but if I have it right, downregulate gene expression via NF-kb, mRNA expression, and reduce CCL5 secretion. Quercetin does seem to occupy parts of the receptor, but there are issues of binding affinity and bioavailability. And efficacy.
Back in the day, after the discovery of the receptor as the entry for the HIV virus, there was a concerted effort to find natural substances that would block the receptor as a treatment for AIDS. These were usually identified from there use in traditional Chinese or Ayurvedic medicine, but also from various ethnic medical traditions. Chinese skullcap and licorice root also came up in a recent search. Nothing was as effective as maraviroc or leronlimab, though they had some promise. Once again, bioavailability and effective dosage. Most of the studies tying these compounds to CCR5 inhibition are preclinical, so they are not a particularly good guide to human use.
I've got to get to work, but will write more later. Something a little more substantial. In the meantime, here's a couple references.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12296246/#abstract1
https://pmc.ncbi.nlm.nih.gov/articles/PMC9913...s-15-00819
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