Summary
Depression is linked to microglial activation, but the precise triggers and downstream pathways remain elusive. Through single-cell RNA sequencing of human blood samples, we find upregulation of the CCL5-CCR5 axis in patients with major depressive disorder
Highlights
CCR5 drives metabolic reprogramming in microglia by binding to VHL
CCR5 aggravates microglia activation and depressive-like behaviors
• Microglial CCR5 promotes complement-mediated synaptic engulfment via H4K12la
• Inhibiting microglial CCR5-lactate-H4K12la axis alleviates depressive-like behaviors https://www.cell.com/cell-reports/fulltext/S2...26)00827-2