Wanted to share some recent publications about CCR5, with

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Conclusion: We identified the IL-15–CCL5–CCR5 circuit as a key driver of CART-BCMA proliferation in CirAE and demonstrated that CCR5 blockade safely restrains CART-BCMA expansion while preserving their anti-myeloma activity. These findings support CCR5-directed targeted strategies to selectively modulate CART expansion without compromising efficacy

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CCR5 (C-C chemokine receptor type 5) is a critical G protein-coupled receptor regulating immune cell trafficking (T cells, macrophages) to inflammation sites, acting as a key modulator in inflammatory diseases, cancer metastasis, and HIV-1 entry. By binding ligands like CCL3, CCL4, and CCL5, it controls immune responses, while the CCR5-Δ32 mutation offers HIV resistance.

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Chemokine Receptor 5 (CCR5) is a G-protein coupled receptor long recognized for its role in immune cell trafficking and as a co-receptor for HIV. However, increasing evidence over recent years has implicated CCR5 as a critical modulator in cancer progression and metastasis. Aberrantly expressed in various tumor types, including aggressive breast, pancreatic and gastric cancers, CCR5 has been associated with enhanced cell survival, proliferation and migration. Its activation, frequently mediated by its ligand CCL5, instigates a cascade of intracellular events that contribute not only to the remodeling of the tumor microenvironment but also to the facilitation of epithelial-mesenchymal transition (EMT) and altered metabolic processes. These processes, in concert, enable tumor cells to disseminate and establish metastatic foci, underscoring the receptor’s potential as both a prognostic biomarker and a therapeutic target.

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CCR5 gene editing aims to mimic the natural HIV-resistant CCR5-Δ32 mutation by using technologies like CRISPR/Cas9, ZFNs, or TALENs to knock out the CCR5 co-receptor, preventing R5-tropic HIV-1 entry into CD4+ T cells. This therapeutic approach in hematopoietic stem cells (HSPCs) or T cells shows potential for establishing a functional HIV cure by creating a resistant immune system.