Wanted to share some recent publications about CCR5, with very brief description of the contents. I apologize in advance if some have already been posted, our molecule is bound to play a big role in the future ..
CCR5 blockade: A therapeutic approach to uncouple CART-BCMA expansion from CART-mediated immune toxicities. | Blood | American Society of Hematology.
https://ashpublications.org/blood/article/146...o-uncouple
Chemokine receptor type-5: a key regulator of immunity, disease pathogenesis, and emerging therapeutic target. - Abstract - Europe PMC
https://europepmc.org/article/med/40779011
Chemokine Receptor 5 and Its Role in Cancer Progression and Metastasis | Nature Research Intelligence
https://www.nature.com/research-intelligence/...micro-4213
CCR5 Gene Editing for HIV Cure Strategies
https://www.frontiersin.org/journals/immunolo...590690/pdf
Yes !!!, we are an emerging therapeutic Target !!!
Enjoy rest of weekend
CCR5 blockade: A therapeutic approach to uncouple CART-BCMA expansion from CART-mediated immune toxicities. | Blood | American Society of Hematology.
https://ashpublications.org/blood/article/146...o-uncouple
.Quote:Conclusion: We identified the IL-15–CCL5–CCR5 circuit as a key driver of CART-BCMA proliferation in CirAE and demonstrated that CCR5 blockade safely restrains CART-BCMA expansion while preserving their anti-myeloma activity. These findings support CCR5-directed targeted strategies to selectively modulate CART expansion without compromising efficacy
Chemokine receptor type-5: a key regulator of immunity, disease pathogenesis, and emerging therapeutic target. - Abstract - Europe PMC
https://europepmc.org/article/med/40779011
Quote:CCR5 (C-C chemokine receptor type 5) is a critical G protein-coupled receptor regulating immune cell trafficking (T cells, macrophages) to inflammation sites, acting as a key modulator in inflammatory diseases, cancer metastasis, and HIV-1 entry. By binding ligands like CCL3, CCL4, and CCL5, it controls immune responses, while the CCR5-Δ32 mutation offers HIV resistance.
Chemokine Receptor 5 and Its Role in Cancer Progression and Metastasis | Nature Research Intelligence
https://www.nature.com/research-intelligence/...micro-4213
Quote:Chemokine Receptor 5 (CCR5) is a G-protein coupled receptor long recognized for its role in immune cell trafficking and as a co-receptor for HIV. However, increasing evidence over recent years has implicated CCR5 as a critical modulator in cancer progression and metastasis. Aberrantly expressed in various tumor types, including aggressive breast, pancreatic and gastric cancers, CCR5 has been associated with enhanced cell survival, proliferation and migration. Its activation, frequently mediated by its ligand CCL5, instigates a cascade of intracellular events that contribute not only to the remodeling of the tumor microenvironment but also to the facilitation of epithelial-mesenchymal transition (EMT) and altered metabolic processes. These processes, in concert, enable tumor cells to disseminate and establish metastatic foci, underscoring the receptor’s potential as both a prognostic biomarker and a therapeutic target.
CCR5 Gene Editing for HIV Cure Strategies
https://www.frontiersin.org/journals/immunolo...590690/pdf
Quote:CCR5 gene editing aims to mimic the natural HIV-resistant CCR5-Δ32 mutation by using technologies like CRISPR/Cas9, ZFNs, or TALENs to knock out the CCR5 co-receptor, preventing R5-tropic HIV-1 entry into CD4+ T cells. This therapeutic approach in hematopoietic stem cells (HSPCs) or T cells shows potential for establishing a functional HIV cure by creating a resistant immune system.
Yes !!!, we are an emerging therapeutic Target !!!
Enjoy rest of weekend
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