CCR5-related signalling may link peripheral immune
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Posted On: 11/09/2025 10:54:46 PM
CCR5-related signalling may link peripheral immune activation to brain chemokine responses in breast cancer
Night time reading
CCR5-related signalling may link peripheral immune activation to brain chemokine responses in breast cancer - ScienceDirect https://share.google/0Zze9PBHJEacgXELZ
Highlights
•Serum CCL4 predicts brain CCL5, suggesting CCR5 links blood-brain crosstalk.
•Brain CCL5 and IL-12p70 are commonly elevated across mammary cancer types.
•Cancer induces broad serum immune changes but brain chemokine responses are select.
Abstract
..."However, the brain's chemokine response suggests selective recruitment of T cells and monocytes/macrophages. Notably, higher serum CCL4 predicted greater hippocampal CCL5 increases, suggesting CCR5-related signalling may draw peripheral immune cells to the brain via increased chemotactic cues"...
"CCL5 is also implicated in T cell recruitment in a Parkinson's disease model, where CCL5 treatment increased Th17 cell infiltration into the brain, worsening neuroinflammation and neurological symptoms (Zhao et al., 2023). CCL5 antagonists also attenuated neuroinflammation and improved cognitive performance in non-cancer contexts (An et al., 2025; D'Antoni et al., 2018a). Despite extensive studies in non-cancerous inflammatory conditions, the role of chemokines and growth factors in cancer-related neuroinflammation remains underexplored"
Night time reading
CCR5-related signalling may link peripheral immune activation to brain chemokine responses in breast cancer - ScienceDirect https://share.google/0Zze9PBHJEacgXELZ
Highlights
•Serum CCL4 predicts brain CCL5, suggesting CCR5 links blood-brain crosstalk.
•Brain CCL5 and IL-12p70 are commonly elevated across mammary cancer types.
•Cancer induces broad serum immune changes but brain chemokine responses are select.
Abstract
..."However, the brain's chemokine response suggests selective recruitment of T cells and monocytes/macrophages. Notably, higher serum CCL4 predicted greater hippocampal CCL5 increases, suggesting CCR5-related signalling may draw peripheral immune cells to the brain via increased chemotactic cues"...
"CCL5 is also implicated in T cell recruitment in a Parkinson's disease model, where CCL5 treatment increased Th17 cell infiltration into the brain, worsening neuroinflammation and neurological symptoms (Zhao et al., 2023). CCL5 antagonists also attenuated neuroinflammation and improved cognitive performance in non-cancer contexts (An et al., 2025; D'Antoni et al., 2018a). Despite extensive studies in non-cancerous inflammatory conditions, the role of chemokines and growth factors in cancer-related neuroinflammation remains underexplored"
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