MGK wrote: Based on above hypothesis, It could tak
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Posted On: 07/23/2025 3:13:18 AM
MGK wrote:
Thanks for your post. Re the time it takes to express PD-L1, I wrote 30-90 days based on Cytodyn's PR from May.
Still seems applicable to me.
Quote:
Based on above hypothesis, It could take some time of treatment with leronlimab (about 3-5 months) before we begin to see PD-L1 rise to a level / threshold where the tumor can be designated as Hot.
Thanks for your post. Re the time it takes to express PD-L1, I wrote 30-90 days based on Cytodyn's PR from May.
Quote:
The company's analysis of metastatic Triple-Negative Breast Cancer (mTNBC) trials showed that 88% (15/17) of patients receiving weekly doses of 525mg or higher experienced significant increases in PD-L1 expression on circulating tumor cells within 30-90 days.
Still seems applicable to me.
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