I wrote Comparison of the previous PR on 7/19 and
Post# of 155333
(Total Views: 358)
Posted On: 07/22/2025 8:09:36 PM
Re: KenChowder #155310
I wrote Comparison of the previous PR on 7/19 and The Compassionate Use Study of LL in BC about 4 years ago, and I talked a good amount about CTCs and CAMLs.
It does not talk about the expression of PD-L1, but if we understand that Progression Free Survival is the time that the treatment buys the patient before incapacitating symptoms return, then we can assimilate it to the length of time it takes for the Cold Tumor to turn Hot.
Based on above hypothesis, It could take some time of treatment with leronlimab (about 3-5 months) before we begin to see PD-L1 rise to a level / threshold where the tumor can be designated as Hot. Remember, this was in mTNBC. MSS mCRC could take longer as the PFS is longer in ColoRectal Cancer than in Triple Negative Breast Cancer under standard of care treatment.
It does not talk about the expression of PD-L1, but if we understand that Progression Free Survival is the time that the treatment buys the patient before incapacitating symptoms return, then we can assimilate it to the length of time it takes for the Cold Tumor to turn Hot.
Quote:
" In 7/19 PR, the relevant biomarkers indicated that the return of the cancer occurred at about the 6 month point after the initial (4) weekly doses of 700mg Leronlimab. By giving only 350mg Leronlimab continuously on a weekly basis, the return of the cancer on average may be appreciated at about 8 - 13 months and was verified as such to be there by measuring the quantity of CAMLs (cancer associated macrophage cells) and CTCs (circulating tumor cells).
Hypothesizing, in the 7/19 PR, the cancer probably started to regrow to produce the CAMLs at about the 5 month point. Switching to the continuous delivery on a weekly basis, we can delay the Active Proliferation of the Cancer until 8 - 10 months while 350mg Leronlimab is continuously injected weekly. "
Based on above hypothesis, It could take some time of treatment with leronlimab (about 3-5 months) before we begin to see PD-L1 rise to a level / threshold where the tumor can be designated as Hot. Remember, this was in mTNBC. MSS mCRC could take longer as the PFS is longer in ColoRectal Cancer than in Triple Negative Breast Cancer under standard of care treatment.
(3)
(0)