I read it yet again…so this is turning “cold�

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I read it yet again…so this is turning “cold” T cells “HOT”. Has such a thing ever been described? We have cold tumors turning hot with the “priming” of LL (how, not, if is the question that plagues me) and now T-cells can turn “hot” from “cold”?

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Leronlimab turns cold tumors hot in two different ways. First it increases the number of T-cells. But T-cells on their own won't necessarily migrate to or attack tumor cells. What would make those T-cells "hot" and ready to kill is antigen presentation to the T-cells. Antigen presenting cells (APCs) engulf and degrade the foreign agents (tumor cells, bacteria, viruses) and degrade them. HLA-DR receptors on the APCs present molecules from the foreign agents to T-cells after binding to the T-cells. The T-cells then will recognize the foreign agents and will migrate and attack. Leronlimab also would upregulate HLA-DRs like maraviroc would. PD-L1 is just a response to the increase in T-cells and does not turn anything hot.