2019 paper: The ability of HIV-1 to remain quies
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Posted On: 07/13/2025 3:50:08 AM
2019 paper:
The ability of HIV-1 to remain quiescent in a latent reservoir in long-lived memory CD4+ T cells is the main barrier to a cure (Chun et al., 1995; Chun et al., 1997a; Chun et al., 1997b; Finzi et al., 1997; Wong et al., 1997). In HIV+ individuals on cART, the primary indication of persistent HIV-1 infection is integrated viral DNA within the genomes of resting CD4+ T cells (Chun et al., 1995). Expression of viral RNA and proteins is limited while the cells remain in a resting state. Infected resting CD4+ T cells are essentially indistinguishable from uninfected cells and are therefore not eliminated by cytolytic effectors.
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Hiv-MDR pg 10:
**...Leronlimab CCR5 RO induces increased frequencies of CCR5+CD4+ T cells **
__
Could we say those are the resting infected cells & qualified as:
"cold into hot" .....
in Hiv ??
The ability of HIV-1 to remain quiescent in a latent reservoir in long-lived memory CD4+ T cells is the main barrier to a cure (Chun et al., 1995; Chun et al., 1997a; Chun et al., 1997b; Finzi et al., 1997; Wong et al., 1997). In HIV+ individuals on cART, the primary indication of persistent HIV-1 infection is integrated viral DNA within the genomes of resting CD4+ T cells (Chun et al., 1995). Expression of viral RNA and proteins is limited while the cells remain in a resting state. Infected resting CD4+ T cells are essentially indistinguishable from uninfected cells and are therefore not eliminated by cytolytic effectors.
___
Hiv-MDR pg 10:
**...Leronlimab CCR5 RO induces increased frequencies of CCR5+CD4+ T cells **
__
Could we say those are the resting infected cells & qualified as:
"cold into hot" .....
in Hiv ??
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