New MANF research related to getting hammered lol
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Posted On: 06/27/2025 4:14:04 PM
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New MANF research related to getting hammered lol enjoy the weekend and be safe!
Spatial Transcriptomics Analysis Uncovers ER stress in MANF-deficient Purkinje Cells Underlying Alcohol-induced Cerebellar Vulnerability in Mice
View ORCID ProfileWen Wen, Hui Li, Li-Chun Lin, Michael S. Chimenti, Henry L. Keen, Mariah R. Leidinger, Di Hu, Zuohui Zhang, Hong Lin, Jia Luo
doi: https://doi.org/10.1101/2025.06.19.660571
In conclusion, the current findings demonstrate that MANF deficient PCs are more susceptible to binge alcohol exposure induced ER stress and neurodegeneration in the adult brain in a sex dependent manner. Such vulnerability is particularly increased in MANF deficient female PCs. We identified overlapping and sex-specific differentially expressed genes in the adult PCs, indicating an alteration in the PC transcriptomics landscape in response to MANF deficiency. Many of the altered genes are involved in protein binding, amino acid transmembrane transportation, and facilitating protein folding. Our study has established a valuable animal model to investigate the role of MANF in PC structure and function as well as molecular mechanisms underlying alcohol-induced PC damages. Further studies are to focus on the biological function of the altered genes, and how they contribute to the increased susceptibility of MANF deficient neurons to alcohol neurotoxicity in the female brain.
https://www.biorxiv.org/content/10.1101/2025.06.19.660571v1
Spatial Transcriptomics Analysis Uncovers ER stress in MANF-deficient Purkinje Cells Underlying Alcohol-induced Cerebellar Vulnerability in Mice
View ORCID ProfileWen Wen, Hui Li, Li-Chun Lin, Michael S. Chimenti, Henry L. Keen, Mariah R. Leidinger, Di Hu, Zuohui Zhang, Hong Lin, Jia Luo
doi: https://doi.org/10.1101/2025.06.19.660571
In conclusion, the current findings demonstrate that MANF deficient PCs are more susceptible to binge alcohol exposure induced ER stress and neurodegeneration in the adult brain in a sex dependent manner. Such vulnerability is particularly increased in MANF deficient female PCs. We identified overlapping and sex-specific differentially expressed genes in the adult PCs, indicating an alteration in the PC transcriptomics landscape in response to MANF deficiency. Many of the altered genes are involved in protein binding, amino acid transmembrane transportation, and facilitating protein folding. Our study has established a valuable animal model to investigate the role of MANF in PC structure and function as well as molecular mechanisms underlying alcohol-induced PC damages. Further studies are to focus on the biological function of the altered genes, and how they contribute to the increased susceptibility of MANF deficient neurons to alcohol neurotoxicity in the female brain.
https://www.biorxiv.org/content/10.1101/2025.06.19.660571v1
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