Gates: Best Bets Hiv cure & Resevoir Consortium
The BMGF formed Frontiers Jan. 2020.
A 2-step program:
1)Develop a Sickle Cell delivery.
2)Then test it for Hiv delivery suppression.
Below is excerpts from the Director of Frontiers, Dr. McCune describing this in Jan. 2020:
"Using state-of-the-art assays, it is hoped that circulating nonviral biomarkers for the rebound-competent reservoir will be discovered in the nonhuman primate, crossvalidated in the human, and assessed for their ability to define the size and quality of the rebound-competent reservoir while on antiretroviral therapy (ART), and the time to viral rebound once ART is discontinued."
( Dr. J did a 2023 43 person LL/ART stop trial )
"....and to simultaneously launch the HIV Reservoirs Consortium. "
"....and with an anticipated “youth bulge” and increasing resistance to ART,1 an uncontrolled epidemic may possibly even grow."
(Our just released Multi-Drug Resistance paper )
(WHO says 30m people are on ART)
(MDR alone could be a company maker)
"....Technically, it has been hard to clarify these unknowns because the viral reservoir resides in tissues (e.g., lymphoid organs, the central nervous system, and the gut) that cannot be easily or comprehensively accessed in PLHIV."
( Dr. Sacha has papers on all these )
"...Meanwhile, even though the NIH and organizations such as amfAR have devoted considerable resources to academic laboratories to discover and develop cures for HIV and to more deeply study the biology of the rebound-competent reservoir, ..."
( Dr. Sacha again )
"...In aggregate, the motivating factors and resources required to bring curative interventions for HIV to resource-limited parts of the world would appear to require new models for discovery, innovation, and risk-sharing partnership."
(Main reason always said GF/ViiV(GSK) liscensing)
"...envisioning two interlocking areas of focus: one that would explore the Current Best Bets for HIV cure and another that would create an HIV Reservoirs Consortium to understand the biology of the rebound-competent reservoir and circulating nonviral biomarkers of it."
(No better Best Bet for Hiv sterilize than Dr. Sacha)
"....Indeed, we view the extension of promising ex vivo gene therapies for sickle cell disease to people in need in sub-Saharan Africa as an imperative; this exercise may also serve as a pathfinder for analogous in vivo gene therapy approaches for an HIV cure."
( "may also serve" --LL is direct to disease & works)
"...Modeling of the epidemic in sub-Saharan Africa, where transmission rates remain high, suggests that an optimal curative intervention should not only suppress (or eliminate) the rebound-competent reservoir within affected individuals but also prevent infection upon re-exposure to virus."
(Dr. Sacha is .."or eliminate"..Dr. McCune is suppress)
"...include interventions that provide a durable effect without repeated administration, for example, extended provision of multiple bNAbs or of eCD4, and/or the induction of a long-lasting and effective antiviral immune response. Given the examples of the “Berlin patient” and the “London patient” as well as intriguing preliminary data with directed CCR5 knockout in peripheral blood cells, interventions ablating this focus might also be pursued."
(100% match to now Berlin LATCH & LL)
"...To introduce such modifications in vivo, it will be necessary to design vectors that can carry the appropriate editing systems to selected target cells after percutaneous (e.g., intravenous or intramuscular) administration."
(Our AAV Vector patent application comes to mind)
"...given commercial opportunities in areas like oncology, it is inevitable that even more options will surface in the future."
(Dr. J -- Oncology is our priority)
"...We have also considered it important to initiate—sooner than later—a vigorous discussion about the ultimate implementation of curative interventions for HIV and sickle cell disease into sub-Saharan Africa."
(Will Leronlimab be more than Hiv via GF/ViiV(GSK)?
"...to be maximally effective and practical, interventions to cure HIV must be designed to suppress the rebound-competent reservoir of HIV over a relatively long period of time, for example, by engaging an immune response that destroys and/or prevents viral spread from cells harboring rebound-competent viral genomes."
(Our ART+bNab+LL results comes to mind)
"...Going into this work, a bottom-line reality must be accepted: the aspirational goal of safe, effective, and widely accessible in vivo gene therapy is daunting and may not be doable."
(That's Sickle Cell development. We know LL works)
"...However, its utility for HIV cure depends on the success of cure designs for sickle cell disease and the continued ability to leverage commercial interest."
(We know LL works)
"...However, its utility for HIV cure depends on the success of cure designs for sickle cell disease and the continued ability to leverage commercial interest."
(We know LL works)
"...We are also working to cement partnerships with multinational pharmaceutical companies that have the expertise, resources, and motivation to bring such therapies into the field and through to commercialization."
(GF/ViiV(GSK) for Hiv?)
(LL for Hiv & Sickle cell ?)
* All of the authors are supported by the Bill & Melinda Gates Foundation.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10112459/
*The HIV Reservoir Consortium is a collaboration of researchers working to find a cure for HIV by identifying and targeting reservoirs of the virus.
*Goals
1) Discover biomarkers that indicate the size and quality of the HIV reservoir
2) Develop strategies to eliminate or control the virus
3) Design clinical trials to test new therapies
______
After reading my short version of this long article, do 1 more thing:
Jan. 2020 Frontiers said 8-10 years from trials.
Contracted the Sickle Cell & Hiv work to Novartis. Check Novartis site & Clinicaltrials.com for Hiv.
Nothing there.
Feb. 21st, 2025 Bill and Melinda Gates Foundation gave Dr. Sacha $1m grant related to resevoir:
https://stocktwits.com/Bio4/message/605280087
https://investorshangout.com/post/view?id=6746404
Bill Gates now says: --- A cure is on the way
We sterilize Hiv.
We are "Best Bet".
Leronlimab is cure.
The BMGF formed Frontiers Jan. 2020.
A 2-step program:
1)Develop a Sickle Cell delivery.
2)Then test it for Hiv delivery suppression.
Below is excerpts from the Director of Frontiers, Dr. McCune describing this in Jan. 2020:
"Using state-of-the-art assays, it is hoped that circulating nonviral biomarkers for the rebound-competent reservoir will be discovered in the nonhuman primate, crossvalidated in the human, and assessed for their ability to define the size and quality of the rebound-competent reservoir while on antiretroviral therapy (ART), and the time to viral rebound once ART is discontinued."
( Dr. J did a 2023 43 person LL/ART stop trial )
"....and to simultaneously launch the HIV Reservoirs Consortium. "
"....and with an anticipated “youth bulge” and increasing resistance to ART,1 an uncontrolled epidemic may possibly even grow."
(Our just released Multi-Drug Resistance paper )
(WHO says 30m people are on ART)
(MDR alone could be a company maker)
"....Technically, it has been hard to clarify these unknowns because the viral reservoir resides in tissues (e.g., lymphoid organs, the central nervous system, and the gut) that cannot be easily or comprehensively accessed in PLHIV."
( Dr. Sacha has papers on all these )
"...Meanwhile, even though the NIH and organizations such as amfAR have devoted considerable resources to academic laboratories to discover and develop cures for HIV and to more deeply study the biology of the rebound-competent reservoir, ..."
( Dr. Sacha again )
"...In aggregate, the motivating factors and resources required to bring curative interventions for HIV to resource-limited parts of the world would appear to require new models for discovery, innovation, and risk-sharing partnership."
(Main reason always said GF/ViiV(GSK) liscensing)
"...envisioning two interlocking areas of focus: one that would explore the Current Best Bets for HIV cure and another that would create an HIV Reservoirs Consortium to understand the biology of the rebound-competent reservoir and circulating nonviral biomarkers of it."
(No better Best Bet for Hiv sterilize than Dr. Sacha)
"....Indeed, we view the extension of promising ex vivo gene therapies for sickle cell disease to people in need in sub-Saharan Africa as an imperative; this exercise may also serve as a pathfinder for analogous in vivo gene therapy approaches for an HIV cure."
( "may also serve" --LL is direct to disease & works)
"...Modeling of the epidemic in sub-Saharan Africa, where transmission rates remain high, suggests that an optimal curative intervention should not only suppress (or eliminate) the rebound-competent reservoir within affected individuals but also prevent infection upon re-exposure to virus."
(Dr. Sacha is .."or eliminate"..Dr. McCune is suppress)
"...include interventions that provide a durable effect without repeated administration, for example, extended provision of multiple bNAbs or of eCD4, and/or the induction of a long-lasting and effective antiviral immune response. Given the examples of the “Berlin patient” and the “London patient” as well as intriguing preliminary data with directed CCR5 knockout in peripheral blood cells, interventions ablating this focus might also be pursued."
(100% match to now Berlin LATCH & LL)
"...To introduce such modifications in vivo, it will be necessary to design vectors that can carry the appropriate editing systems to selected target cells after percutaneous (e.g., intravenous or intramuscular) administration."
(Our AAV Vector patent application comes to mind)
"...given commercial opportunities in areas like oncology, it is inevitable that even more options will surface in the future."
(Dr. J -- Oncology is our priority)
"...We have also considered it important to initiate—sooner than later—a vigorous discussion about the ultimate implementation of curative interventions for HIV and sickle cell disease into sub-Saharan Africa."
(Will Leronlimab be more than Hiv via GF/ViiV(GSK)?
"...to be maximally effective and practical, interventions to cure HIV must be designed to suppress the rebound-competent reservoir of HIV over a relatively long period of time, for example, by engaging an immune response that destroys and/or prevents viral spread from cells harboring rebound-competent viral genomes."
(Our ART+bNab+LL results comes to mind)
"...Going into this work, a bottom-line reality must be accepted: the aspirational goal of safe, effective, and widely accessible in vivo gene therapy is daunting and may not be doable."
(That's Sickle Cell development. We know LL works)
"...However, its utility for HIV cure depends on the success of cure designs for sickle cell disease and the continued ability to leverage commercial interest."
(We know LL works)
"...However, its utility for HIV cure depends on the success of cure designs for sickle cell disease and the continued ability to leverage commercial interest."
(We know LL works)
"...We are also working to cement partnerships with multinational pharmaceutical companies that have the expertise, resources, and motivation to bring such therapies into the field and through to commercialization."
(GF/ViiV(GSK) for Hiv?)
(LL for Hiv & Sickle cell ?)
* All of the authors are supported by the Bill & Melinda Gates Foundation.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10112459/
*The HIV Reservoir Consortium is a collaboration of researchers working to find a cure for HIV by identifying and targeting reservoirs of the virus.
*Goals
1) Discover biomarkers that indicate the size and quality of the HIV reservoir
2) Develop strategies to eliminate or control the virus
3) Design clinical trials to test new therapies
______
After reading my short version of this long article, do 1 more thing:
Jan. 2020 Frontiers said 8-10 years from trials.
Contracted the Sickle Cell & Hiv work to Novartis. Check Novartis site & Clinicaltrials.com for Hiv.
Nothing there.
Feb. 21st, 2025 Bill and Melinda Gates Foundation gave Dr. Sacha $1m grant related to resevoir:
https://stocktwits.com/Bio4/message/605280087
https://investorshangout.com/post/view?id=6746404
Bill Gates now says: --- A cure is on the way
We sterilize Hiv.
We are "Best Bet".
Leronlimab is cure.
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