5 count em 5! New MANF research articles to start
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Posted On: 02/22/2025 11:35:37 PM
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5 count em 5! New MANF research articles to start the year. Our time will come.
1) MANF in Chemotherapy-induced peripheral neuropathy (CIPN) (90% of chemo patients experience this)
Neuropharmacology Volume 268, 1 May 2025, 110342
Mesencephalic astrocyte-derived neurotrophic factor (MANF): A novel therapeutic target for chemotherapy-induced peripheral neuropathy via regulation of integrated stress response and neuroinflammation
To conclude, our study underscores the potential of MANF as a viable therapeutic target for CIPN, manifesting its ability to modulate ISR and neuroinflammation. These insights recommend that continued exploration of MANF-centered approaches could facilitate the advancement of more efficacious interventions for this incapacitating chemotherapy complication.
https://www.sciencedirect.com/science/article...i-endpoint
2) MANF in intervertebral disc degeneration (IDD). MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression
Sci Rep. 2025 Jan 2;15(1):476.
doi: 10.1038/s41598-024-84167-9
https://pubmed.ncbi.nlm.nih.gov/39747250/
3) MANF in Acute lung injury (ALI). Involvement of PRDX6 in the protective role of MANF in acute lung injury in rats
Xiuli Yang et al. Exp Lung Res. 2025.
Results: In WT rats, MANF reversed the increases of PRDX6, ROS overgeneration, and pyroptosis-related protein-Gasdermin D (GSDMD) induced by LPS challenge. In PRDX6-/- rats, ROS generation, the protein level of GSDMD-N, and lung injury were not significantly decreased after human recombinant MANF administration in LPS-induced ALI.
https://pubmed.ncbi.nlm.nih.gov/39861940/
4) MANF as a Intrahepatic cholangiocarcinoma (ICC) biomarker
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma
Qiong Mei et al. Cell Death Differ. 2025.
Cell Death Differ. 2025 Feb 19.
doi: 10.1038/s41418-025-01460-4.
https://pubmed.ncbi.nlm.nih.gov/39972058/
5) MANF in Diabetic peripheral neuropathy (DPN)
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Restricts Inflammatory Progression through Limiting Macrophage Infiltration in DRG and Sciatic Nerve during Diabetic Peripheral Neuropathy
Peng Dai et al. ACS Chem Neurosci. 2025.
Hide details
ACS Chem Neurosci. 2025 Feb 19. Doi: 10.1021/acschemneuro.5c00021.
In summary, our research underscores MANF's potential as a novel therapeutic target for DPN, particularly due to its anti-inflammatory properties. Further exploration of MANF could lead to the development of more effective treatments for this debilitating aspect of diabetes.
https://pubmed.ncbi.nlm.nih.gov/39970444/
1) MANF in Chemotherapy-induced peripheral neuropathy (CIPN) (90% of chemo patients experience this)
Neuropharmacology Volume 268, 1 May 2025, 110342
Mesencephalic astrocyte-derived neurotrophic factor (MANF): A novel therapeutic target for chemotherapy-induced peripheral neuropathy via regulation of integrated stress response and neuroinflammation
To conclude, our study underscores the potential of MANF as a viable therapeutic target for CIPN, manifesting its ability to modulate ISR and neuroinflammation. These insights recommend that continued exploration of MANF-centered approaches could facilitate the advancement of more efficacious interventions for this incapacitating chemotherapy complication.
https://www.sciencedirect.com/science/article...i-endpoint
2) MANF in intervertebral disc degeneration (IDD). MANF overexpression ameliorates oxidative stress-induced apoptosis of human nucleus pulposus cells by facilitating mitophagy through promoting MFN2 expression
Sci Rep. 2025 Jan 2;15(1):476.
doi: 10.1038/s41598-024-84167-9
https://pubmed.ncbi.nlm.nih.gov/39747250/
3) MANF in Acute lung injury (ALI). Involvement of PRDX6 in the protective role of MANF in acute lung injury in rats
Xiuli Yang et al. Exp Lung Res. 2025.
Results: In WT rats, MANF reversed the increases of PRDX6, ROS overgeneration, and pyroptosis-related protein-Gasdermin D (GSDMD) induced by LPS challenge. In PRDX6-/- rats, ROS generation, the protein level of GSDMD-N, and lung injury were not significantly decreased after human recombinant MANF administration in LPS-induced ALI.
https://pubmed.ncbi.nlm.nih.gov/39861940/
4) MANF as a Intrahepatic cholangiocarcinoma (ICC) biomarker
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma
Qiong Mei et al. Cell Death Differ. 2025.
Cell Death Differ. 2025 Feb 19.
doi: 10.1038/s41418-025-01460-4.
https://pubmed.ncbi.nlm.nih.gov/39972058/
5) MANF in Diabetic peripheral neuropathy (DPN)
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Restricts Inflammatory Progression through Limiting Macrophage Infiltration in DRG and Sciatic Nerve during Diabetic Peripheral Neuropathy
Peng Dai et al. ACS Chem Neurosci. 2025.
Hide details
ACS Chem Neurosci. 2025 Feb 19. Doi: 10.1021/acschemneuro.5c00021.
In summary, our research underscores MANF's potential as a novel therapeutic target for DPN, particularly due to its anti-inflammatory properties. Further exploration of MANF could lead to the development of more effective treatments for this debilitating aspect of diabetes.
https://pubmed.ncbi.nlm.nih.gov/39970444/
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