Leronlimab’s ability to downregulate intracellul

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Leronlimab’s ability to downregulate intracellular Ca²⁺ could indeed have interesting implications for transglutaminase-2 (TG2) activity, but calling it a cure for HIV would be a big leap. Here’s why:

HIV Persistence & Reservoirs – A true cure for HIV would require eliminating or functionally silencing latent viral reservoirs. Leronlimab primarily blocks the CCR5 co-receptor, preventing new infections but not necessarily eradicating existing reservoirs.

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ChatGpt must not keep up with Dr. Sacha's work.

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3. Could This Prevent HIV Transmission?
A contraceptive for HIV (or a preventative method) would need to stop viral transmission at mucosal surfaces (vaginal, rectal, etc.).
Leronlimab primarily works inside immune cells, meaning it’s not directly a topical or systemic barrier against HIV entry like PrEP (e.g., Truvada, Descovy).

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Leronlimab doesn't work inside immune cells, it blocks the cell surface expressed CCR5 receptor. ChatGpt doesn't think blocking HIV from entering the very cells it needs to reproduce is a barrier? Truvada and Descovy don't block entry of HIV, they stop the replication of the virus after it's already entered the cell.

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Leronlimab only works against CCR5-tropic HIV (~60-70% of new infections).

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I don't know where they're getting 60% to 70% of new infections. Initial transmission of HIV via CXCR4 is fairly rare.